Symptoms
Genotypes
Causes/Testable
100

What is the most common symptom that occurs in patients with sickle cell anemia?

Episodes of pain.

Periodic episodes of extreme pain, called pain crises, are a major symptom of sickle cell anemia

100

If both parents have the genotype AS, what would the first child genotype be?

The first child genotype would be 1 AA, 2 AS, and 1 SS.

100

What are the causes of SCD?

To be born with sickle cell disease, a child has to inherit a copy of the sickle cell gene from both their parents.

200

Give 2 example of symptoms regarding sickle cell that are treatable?

  1. Pain crises

  2. Infections

200

What are the possible genotypes of offspring if one parent is AS and the other is AA?

From this, the possible genotypes of the offspring are:

  • AA (homozygous)

  • AS (heterozygous)

So the offspring could either be AA or AS. The ratios would be 50% AA and 50% AS.


200

How can you check for sickle cell anemia?

A blood test can check for the form of hemoglobin that underlies sickle cell anemia.

300

What are some chronic complications that come with having sickle cell anemia? (2 examples)

  1. Acute Chest Syndrome

  2. Stroke

300

If AA represents normal hemoglobin and SS represents sickle cell hemoglobin, what phenotypes would you expect from parents with genotypes AS and SS?

From this square, the possible genotypes of the offspring are:

  • AS (heterozygous, normal hemoglobin but a carrier for sickle cell)

  • SS (homozygous, sickle cell hemoglobin)

The resulting phenotypes would be:

  • 50% with normal hemoglobin (phenotype AS, carriers)

  • 50% with sickle cell hemoglobin (phenotype SS)

So, you can expect that half of the offspring will have normal hemoglobin (carriers) and the other half will have sickle cell hemoglobin.

300

     There's a cure for sickle cell anemia?

                     True or False

False

400

When was sickle cell anemia discovered?

Sickle cell anemia was first described in the medical literature in 1910.

400

If two AS individuals have children, what is the probability of having a child with the genotype SS?

From this square, the possible genotypes of the offspring are:

  • AA (homozygous normal)

  • AS (heterozygous, carrier)

  • AS (heterozygous, carrier)

  • SS (homozygous sickle cell)

The resulting genotypes are:

  • 1 AA = 25%

  • 2 AS = 50%

  • 1 SS = 25%


So, there is a 25% probability of having a child with the genotype SS.

400

Somebody around you can cause you to catch sickle cell anemia.

                        True or False

False

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