Simple Dosage Form Jeopardy

Powders & Blending

100

A powder is best defined as what physical type of substance?

Finely divided particles

200

What blending method uses a pill tile?

Spatulation

300

What is the name of the process where equal volumes of drug and diluent are repeatedly mixed?

Geometric dilution

400

Name a type of pharmaceutical powder that is NOT pressurized.

Correct answers:
Bulk Powders

Dusting Powders

Douche Powders

Divided Powders

500

List 3 blending methods mentioned.

Possible answers:

Spatulation
Trituration
Sifting
Tumbling

Tablets & Capsules

100

Tablets must have predictable ... ?

Dissolution

200

Which capsule type has a plasticizer:gelatin ratio of 0.8:1?

Soft gelatin capsules

300

Name an advantage of capsules over tablets.

Possible answers:
Better masking of taste/aroma
Easier to formulate, manufacture, vary dose, combine APIs, swallow
Suitable for blinded clinical trials
Useful for extemporaneous compounding by Rph

400

What excipient helps a tablet break apart in the GI tract?

Disintegrant

500

A size 1 capsule has a volume of approximately how many mL?

0.5 mL

Aerosols & Inhalers

100

Name the 3 types of Aerosol delivery devices

MDIs, DPIs, Nebulizers

200

What particle size reaches the alveolar region?

< 2 um

300

What percentage of aerosol propellants are liquefied gases?

90%

400

Name one QC test for aerosols

Spray pattern

Leak test

Vapor pressure

Flame extension

500

Name the device that uses aerodynamic cut-off diameters at 15, 30, 60, and 100 L/min?

Particle Classifying Cascade Impactor

PK/PD & Equations

100

PK is Concentration vs. __

Time

200

PD is Concentration vs. __

Effect

300

In the Henderson-Hasselbalch equation, pH = pKa + log ( __ / __ )

[base/acid]

[A-]/[HA]

400

At pH < pKa, which species predominates for a weak acid?

HA (unionized acid)

500

Flumequine (an acid) has a pKa of what value?

6.27

Drug Delivery & Routes

100

What route avoids first-pass metabolism?

Inhalation

200

Name one major parenteral route

Intravenous (IV)

Intramuscular (IM)

Subcutaneous (SC)

300

What barrier prevents many drugs from entering the CNS?

Blood-brain barrier

400

Which system distributes nanoparticles throughout the organism?

Lymphatic system

500

Name 3 reasons dosage forms are needed (from the big list)

1- Accurate dose
2- Protection of drug
3- Protection from gastric juice
4- Masking taste and odor
5- Placement of drugs within body tissues
6- Sustained release medication
7- Controlled release medication
8- Optimal drug action
9- Insertion of drugs into body cavities
10- Make insoluble drugs soluble