Potpourri
Expt & Humane Endpoints
Unexpected Outcomes
Unexpected Outcomes
Physical Restraint
Food and Fluid Regulation
Other special considerations
(non-pharm compounds, multiple survival surgery, ag or field studies)
(non-pharm compounds, multiple survival surgery, ag or field studies)
100
Experimental Endpoints, unexpected outcomes, physical restraint, multiple survival surgeries, food and fluid regulations, use of non-pharmaceutical chemicals, and non-traditional animals (field studies or livestock).
What are the special considerations to which the IACUC should pay particular attention, based on the potential impact on animal welfare of each?
100
When the scientific aims and objectives have been reached
What is the experimental endpoint of a study?
100
The use of manual or mechanical means to limit some or all of an animal's movement for the purpose of examination, collection of samples, drug admin, therapy, or experimental manipulation.
What is physical restraint?
100
• scheduled access to food or fluid in which the animal has unlimited access to food or fluid for a specific time daily.
• restricted access, in which the total amount of food or fluid is strictly monitored or controlled. Calorie restriction for experimental purposes should be described here.
What is food or fluid regulation?
How is food or fluid regulation defined in the ARROW protocol?
100
Surgeries are included in and essential components of a single research project or protocol, scientifically justified by the investigator, necessary for clinical purposes.
What may justify multiple survival surgeries on a single animal?
200
These procedures have the potential for unrelieved pain or distress or other animal welfare concerns.
Why do these procedures require special consideration by the IACUC?
200
The point in a study at which pair or distress in an experimental animal is prevented, terminated, or relieved.
What are humane endpoints?
200
The animal should be removed from the study.
What should be done if an animal does not adapt to a necessary restraint system?
In addition to veterinary care, what may be necessary if lesions, illness, or severe behavioral change result from physical restraint?
200
Calorie restriction as directed by a veterinarian for purposes of weight control.
Fasting before sedation or use of anesthesia, or to standard presurgical fasting or withholding of fluids.
What is NOT considered to be food or fluid regulation?
200
Cost savings
What is never a sufficient justification for performing multiple survival surgeries on a single animal?
What is not a sufficient justification for the use of non-pharmaceutical substances in animals? (except in rare instances....)
300
A small-scale research project that can be required by the IACUC, especially if little is known about a specific procedure or the skills of a study team.
What is a pilot study
300
Precise definition of the humane endpoint, frequency of observation, training of personnel responsible for assessment and recognition, and response required upon reaching the humane endpoint.
What information should be considered in the IACUC's assessment of appropriate humane endpoints in a protocol?
300
Chairing of nonhuman primates
Backpack-fitted infusion pumps in dogs
Holding awake mice still while under an imaging system
Which of the following is not considered physical restraint?
300
A description of the food or fluid regulation, scientific justification, monitoring, recordkeeping, a question about pain/distress, and any anesthesia/analgesia to be used.
What is included in the ARROW section for food and fluid regulation?
300
Consult with relevant professional societies and available guidelines.
Get veterinary input.
Consult with qualified wildlife biologists.
What are some recommendations for IACUCs reviewing field studies?
400
The IACUC must weigh the objectives of the study against potential animal welfare concerns. By considering opportunities for refinement, the use of appropriate non-animal alternatives, and the use of appropriate numbers of animals, the Institution, the IACUC, and the study team can begin to address their shared obligations for humane animal care and use.
How can the institution and PI address their shared obligation for human animal care?
400
Tumor models, infectious diseases, vaccine challenges, pain studies, trauma models, monoclonal antibody production, organ or system failure, and models of cardiovascular shock.
Give some examples of studies that commonly require special consideration.
400
False
Any true or false question related to the topic.
Restraint devices can be considered normal housing
Physical restraint does not need to be justified
Additional observation is not required when physical restraint is used
......
400
Use of a highly preferred food or fluid as a positive reinforcement.
What is an appropriate alternative to the use of food/fluid regulation for conditioned response/behavorial testing studies?
400
Daily double: You will receive double points if this question is correct! But if incorrect, you lose 400 points!
The Guide for the Care and Use of Laboratory Animals applies to agricultural animals used for biomedical research.
What guidance document applies to agricultural animals used for biomedical research?
500
Scientific justification and IACUC approval are required for these special accommodations outside the requirements of the Guide
What are departures
500
The phenotype that results from genetically modified animals is often unanticipated.
What is the reason additional questions are asked when genetically modified animals are being developed?
500
Acclimatization, monitoring, justification, painful/distressful, and analgesic/anesthetic regimen are all part of this section of the ARROW protocol.
What is the physical restraint table/section?
Or- what questions are asked in the physical restraint section?
500
Daily food and fluid consumption, hydration status, behavorial or clinical changes
What records should be kept for food/fluid regulation studies?
What records may be used as criteria for the temporary or permanent removal of an animal from a protocol?
500
Approval from the USDA/APHIS as well as strong scientific justification.
What is required in order for USDA-regulated animals to be subjected to multiple survival surgeries in separate research protocols?