Not So Super Villains
Sandman if he was more hydrated.
Hydro-man
The iconic convoluted storyline with all the clones.
Clone Saga
How Spiderman's parents died.
Plane Crash
Spiderman's first supervillain, tainting his public image forever.
Chameleon
Norman & Harry Osborne
Someone named Phineas, and not unlike the Phineas from Phineas & Ferb.
The Tinkerer
Spiderman makes a deal with Mephisto for Aunt May's life in exchange for his marriage with Mary Jane.
One More Day
The super villain that took control of Spiderman's body.
Doctor Octavius
In the MCU, the villain who frames spiderman for his destruction and plans, outing him to the public.
Mysterio
The real name of Spiderman's sexiest ex (and villain).
Felecia Hardy
The embodiment of "We can be bees", this guy took the word hivemind too literally.
Swarm
The storyline in which Spiderman unveils his identity to the world, amidst a much more significant superhero conflict.
Civil War
Mary Jane's husband.
Paul
The most iconic clone of spiderman, believing he was the real one to the point of making Spiderman (and the writers) doubt themself.
Ben Reilly/Scarlet Spider
The real name of the masked Spiderman villain, the Chameleon. (Hint: Kraven's Russian half brother)
Demitri
Sharing the name of a villain from 'The Flash', this Aussie isn't as high ranking.
Boomerang
DAILY DOUBLE
Maximum Carnage
The man who ripped out and ate Spiderman's eye.
Morlun
The original spiderman clone, starting off the clone saga and one of the people known as the Scarlet Spider.
Kaine
DAILY DOUBLE
Norman Osborne
An influencer themed around an arcade game, this woman is the embodiment of an annoying millenial.
Screwball
Kraven's final besting of Spiderman, burying him alive and committing suicide after completing his final goal.
Kraven's Last Hunt
The Retconned storyline in which Gwen Stacy had an affair with Norman Osborne
"Sins Past"
An evil mindless toothed duplicate of Spiderman, often a tool in the schemes of other villains.
Doppelganger
At least two of the people under Mysterio's fishbowl helmet.
Quentin Beck, Daniel Berkhart, and Francis Klum (or Mysterion)