Information about Trazodone
What is the Brand name for Trazodone
Desyrel
What is the Dosage form?
Oral tablets or solution
What is the black box warning?
Increased suicidal thoughts in ages 18-24.
What should patients avoid and why?
Alcohol, because it increases drowsiness and CNA depression
What is the MNEMONIC for Trazodone?
ASLEEP
What condition does Trazodone treat?
MDD
What should be taken with Trazodone?
Take with food
What symptoms should be reported to doctor if they occur?
1. Worsening mood or suicidal thoughts
2. Symptoms of serotonin syndrome
3.Prolonged, pain erection
What should be done with caution when on Trazodone?
Driving/machinery
What class does Trazodone belong to?
Serotonin antagonist and reuptake inhibitor
What three neurotransmitters are effected by Trazodone?
1.Serotonin
2.Histamine-1
3.Alpha-1
Two weeks or longer
What should a care-giver report?
Care-givers should report sudden behavioral changes or worsening depression early
What should a patient do if they miss a dose?
Take when remembered, skip if near the next dose (never double up)
What side effect is rare?
Priapism
What is the MOA of trazodone?
Blocks specific serotonin receptors and slows reuptake to balance brain chemistry and promote calm
How do you correctly stop taking Trazodone?
Taper off slowly to avoid withdrawal symptoms
What age group can be impacted by the Black box warning?
Children, adolescents and young adults (18-24)
What can this medication cause?
Orthostatic hypotension
What side effects puts patients at risk of falls?
Dizziness, lightheadedness, or excessive drowsiness
What is the natural substance in Trazodone?
Serotonin
What time of day should you take Trazdone?
Take at the same time per day
What is Trazodone contraindicated in?
1. MAOI
2. IV methylene Blue
3. Linezolid
What are elderly patients at higher risk for?
Orthostatic hypotension
Name all side effects
Abdominal pain/nausea/vomiting/stomach upset
Sedation/somnolence
Lightheadness/dizzy
Extreme drop in BP (orthostatic hypotension)
Elevated heart rate
Priapism