Trazodone
What is the Brand name for Trazodone?
Desyrel
What is the MOA of Trazodone?
Trazodone blocks reabsorption of serotonin along with blocking histamine- 1 receptors and alpha- 1 adrenergic receptors
What is the black box warning for Trazodone?
Increased suicidal thoughts (18-24 y.o.)
Why should you take immediate-release tablets with food?
What is the 'A' side effect in the mnemonic 'ASLEEP'?
Abdominal pain/nausea/vomiting/upset stomach
What is the primary indication for Trazodone?
Major Depressive Disorder
What does serotonin do?
Regulate mood
What is trazodone contraindicated with concurrent use of? (There are 3)
MAOI's, linezolid, or intravenous methylene blue (within 14 days of discontinuation)
Why should you avoid driving or doing activities that require mental alertness or coordination?
This medication can cause drowsiness and sedation
What is the 'S' side effect in the mnemonic 'ASLEEP'?
Sedation/Somnolence
What is the off label use for Trazodone?
Insomnia
What does histamine- 1 being blocked do?
Cause drowsiness
What type of patients should be cautious with Trazodone?
Patients with seizures or a history of seizures, brain damage, head trauma, or concurrent medications that can lower seizure threshold
What is advised against while taking Trazodone?
CNS depressants and alcohol
What is the 'L' side effect in the mnemonic 'ASLEEP'?
Lightheadedness/dizzy
What is the mnemonic for Trazodone's side effects?
ASLEEP
What does Alpha- 1 being blocked do?
Cause hypotension
WHAT is contraindicated in patients with known hypersensitivity to Trazodone?
Trazodone or any component in its formulation
Why should you rise slowly when taking Trazodone?
This medication can cause orthostatic hypotension
What are both of the 'E' side effect in the mnemonic 'ASLEEP'?
Extreme drop in BP
Elevated heart rate
What category is Trazodone?
Serotonin Antagonist and Reuptake Inhibitors (SARIs)
What do 'inhibiting' and 'reuptake' mean?
Blocking, reabsorption
What is the difference between contraindications and precautions?
A contraindication is strictly prohibited
A precaution is a warning telling you to be cautious
In what patients is the risk for orthostatic hypotension higher?
Elderly patients
What is the 'P' side effect in the mnemonic 'ASLEEP'?
Priapism