Neoplasia
What diagnostic tool can be used to diagnose neoplasia by looking at clonality?
PCR for Antigen Receptor Rearrangement (PARR)
When is a bone marrow aspirate definitively indicated?
with persistent cytopenias, esp. if >1
pancytopenia (multiple cell lines affected)
For high-grade canine lymphoma, what is the most aggressive form of treatment?
What medications should be initiated in a patient with a mast cell tumor exhibiting signs of histamine release (e.g., pruritus and erythema)?
H2 antagonists (famotidine) & PPIs (omeprazole) reduce gastric acid production
H1 antagonists (diphenhydramine) reduce itch and histamine effects
What is the most common location for osteosarcoma?
metaphyseal region of long bones
What is the most common paraneoplastic syndrome?
anemia
A patient has marked leukocytosis and blastic cells in their bloo on a smear. A CD34 molecule is also detected on an antibody panel. What is most likely diagnosis?
Acute leukemia
what drugs make up CHOP?
cyclophosphamide, doxorubicin, vincristine, prednisone/olone
In a patient with a high-grade mast cell tumor that has been fully excised with clean margins and no metastasis, what is the recommended approach to postoperative chemotherapy?
vinblastine (& prednisone)
What is the MST with amputation alone for osteosarcoma?
6 months
This type of tumor appears pseudoencapsulated.
soft tissue sarcomas
A _____ response is indicative of neoplasia.
What is the most common location of feline lymphoma?
GIT
This medication is more toxic than IV chemotherapy. It is given orally. It inhibits the phosphorylating region on cell surface. This causes shrinkage.
Palladia (toceranib)
What chemotherapy is recommended and provides MST of 12 months for osteosarcoma?
BONUS: When is chemotherapy not recommended?
carboplatin
BONUS: if pain is not controlled
With a local tumor with local contral, which tumors can be cured?
low grade soft tissue sarcoma
well-differentiated MCT
Which type of leukemia has a better prognosis?
B-cell
Small cell lymphoma presents very similarly to what?
inflammatory bowel disease (IBD)
This disease of felines can directly cause lymphoma.
FeLV
What is the most common location for hemangiosarcoma?
Spleen
Where do acute side effects of radiation therapy occur?
in rapidly proliferating tissue, such as skin, oral mucosa, or GIT
Multiple myeloma affects what type of cell?
plasma cells
How is low grade lymphoma treated?
chlorambucil and prednisone
What is the median survival for a cat with an intestinal MCT? What are treatment options?
2 mths to 1.5 years
surgery with wide margins and/or tyrosine kinase inhibitors
Why is prophylactic splenectomy not recommended in patients at risk for hemangiosarcoma?
cell of origin does not necessarily originate in the spleen. removing the spleen wont stop it from occurring somewhere else in the body