ZES
What genetic condition predisposes to ZES?
MEN1
MCC Upper GI bleed
Peptic ulcer disease
Linear mucosal lacerations
Mallory-Weiss tear
Describe in one sentence the pathogenesis/pathophys of ZES
Too much gastrin make too much acid which cause damage
What are the two main ways PUD occurs?
H. pylori and NSAIDs
Hematemesis after a week of profuse vomiting?
Mallory-weiss
Fasting serum gastrin level or secretin stimulation test
Epigastric pain, melena, history of NSAIDs, or H pylori
PUD
Superficial mucosal breaks in the esophagus or stomach/duodenum confined to the mucosa?
Erosive esophagitis/gastritis
What is the treatment option for symptom control?
PPI
What is the next step in suspected esophageal/gastric variceal hemorrhage?
Urgent endoscropy
Heartburn, dyspepsia, or epigastric discomfort with low-volume bleeding
Erosive esophagitis/Gastritis
What is the prognosis of ZES if treated early?
>80% survival at 15 years
Cause of UGIB but carries a higher mortality rate than non variceal causes?
Large-volume bright red hematemesis, associated with signs of liver disease
Esophageal/Gastric variceal hemorrhage