Innate Immunity
Name an innate immune cell that is capable of phagocytosis?
Macrophage, Dendritic cell, Neutrophils
Where do B-lymphocytes mature?
Bone Marrow
What cell recognizes antigen presented by MHC class I molecules?
T-cytotoxic cell
What immunoglobulin crosses the placenta?
IgG
Which immunoglobulin(s) is capable of activating complement?
IgG - 2 molecules needed
IgM - 1 molecule needed
Innate immune cells like macrophages have receptors on their surface to recognize ________ on the surface of bacterial pathogen.
PAMPs
What cells secrete antibodies?
Plasma cells
What MHC molecule is found only on antigen-presenting cells such as macrophages, dendritic cells, and B cells.
MHC class II molecules
What antibody is produced first in the primary immune response?
IgM
What acts as a powerful opsonin in the complement cascades?
C3b
What acute phase protein is used clinically as a general marker of acute inflammation?
C-reactive protein
What immunoglobulins are on the surface of a mature B-cell?
IgM
IgD
MHC class II molecules present _______ to T-helper cells.
Extracellular or exogenous antigen
What immunoglobulin is play a role in mucosal immunity?
IgA
Patients with C5-C9 complement deficiency have recurrent infections with which bacterial genus?
Neisseria
What innate immune cell is the first line of defense against virally infected cells, tumor cells, and intracellular pathogens?
Natural Killer cells (NK)
What marker is present on the surface of T-helper cells?
CD4
What is the main role of MHC class I and class II molecules in the immune system?
Presenting foreign antigen to T-cells.
What immunoglobulin increases in allergic response?
IgE
At what point do all 3 complement pathways converge?
C3
Name one characteristic of the innate immune system.
Fast acting
No memory
Non-specific
Immunity born with
Where do most adaptive immune cells (T and B lymphocytes) first encounter their specific pathogen (antigen)?
Secondary lymphoid organs ((lymph nodes, spleen, MALT, CALT)
A substance that must combine with a carrier molecule to elicit an immune response is called a ____.
What portion of the immunoglobulin (antibody)molecule does the foreign antigen bind to?
What part of the immunoglobulin molecule does complement bind?
Fc region