Name that glioma!
A diffusely infiltrating brain tumor with IDH mutation and 1p/19q codeletion belongs to this glioma subtype.
What is oligodendroglioma?
When this enzyme is expressed, it can repair the DNA lesions produced by temozolomide, contributing to treatment resistance.
What is MGMT?
Dr. Dinkin attended this medical school in 2002.
What is Weill Cornell Medical College?
Weill Cornell's medical school essentially exists because a group of physicians became unhappy with this other NYC university, broke away after a court dispute, and brought much of the faculty and 215 students with them to form Cornell University Medical College in 1898
What is NYU?
This highly malignant adult brain tumor can cross the corpus callosum, producing a classic “butterfly” appearance.
What is glioblastoma?
Methylation of this DNA-repair gene’s promoter predicts improved response of glioblastoma to temozolomide.
What is MGMT?
Dinkin's first musical, performed at Harvard's Leverett House Theater, had this wonderfully bizarre title and won a Harvard Arts First Award. Landslide Lyndon - LBJ the Musical?
What is The Prophet and the Janitor?
WCM also credits its researchers with conducting the first experiment of this type, now considered a cornerstone of rigorous clinical drug trials.
What is a double-blind controlled experiment?
This glioma is automatically considered grade IV
What is glioblastoma?
Gliomas with mutations in either of these two metabolic enzymes generally have distinct biology and better prognosis than their wild-type counterpart.
What is IDH1 and IDH2?
Durring Lecture this week, Dr. Dinkin played this instrument for the class.
What is a guitar?
Cornell's published institutional history describes classified research partnerships with this U.S. intelligence agency.
What is the CIA?
An adult has a diffusely infiltrating astrocytic tumor that is IDH-mutant but does not have a 1p/19q codeletion. This diagnosis is most likely.
What is Astrocytoma, IDH Mutant?
A glioblastoma with an unmethylated MGMT promoter is relatively resistant to temozolomide because tumor cells retain this cellular function.
What is repair of alkylated DNA?
Dr. Dinkins father is at least this many decades old.
What is 10 decades?
This physician spent decades at Cornell developing the cytologic screening technique (PAP test) that revolutionized cervical cancer detection and now bears his name.
Who is George Papanicolaou?
An older adult has an aggressive cerebral tumor showing necrosis, microvascular proliferation, EGFR amplification, and an IDH-wildtype genotype.
What is glioblastoma, IDH-wildtype?
Some gliomas contain activating fusions involving this receptor family, making them potentially susceptible to drugs such as larotrectinib.
What are NTRK fusions?
The Neuro-Ophthalmology service Dr. Dinkin directs offers Botox—not primarily for wrinkles, but for conditions including these involuntary eyelid/facial contractions.
What are blepharospasm and hemifacial spasm?
In 1955, Cornell biochemist Vincent du Vigneaud won the Nobel Prize in Chemistry for work involving the first synthesis of this hormone.
What is Oxytocin?