Circuit
The hippocampus is important for which types of memories?
episodic and spatial memories
Finish the statement:
Cells that ____ together _____ together.
Fire; Wire
True or False:
APV impaired learning of the location of the hidden platform.
True
True or False:
Longer latency in the Morris Water Maze would mean an experimental manipulation improved memory functions.
False
Fill in the blank:
The hippocampus stimulation pathway is as follows:
Enotorhinal -> Dentate Gyrus -> ____ -> CA1
CA3
What does fEPSP stand for?
Field Excitatory Postsynaptic Potential
What region(s) of the hippocampus did Tonegawa's group delete the GluN1 subunit from?
CA1 and CA3
How can you tell the strength of the synaptic connection on an fEPSP graph?
By looking at the slope.
What connects the CA3 pyramidal cells to the CA1 pyramidal cells?
Schaffer collaterals
What is theta burst stimulation(TBS)?
TBS a series of very fast electrical stimulations that induce LTP.
True or False.
The Tonegawa experiment we studied in class deleted the GluN1 subunit from the Dentate Gyrus.
False; the Tonegawa experiment we studied in lecture deleted the GluN1 subunit from the CA1 and CA3 regions.
If I stimulated the Schaffer collateral cell and measured the resulting signal through an extracellular recording electrode, would the slope of the resultant action potential be negative or positive?
Negative
What type of cell structure are the CA3 and CA1 regions of the hippocampus comprised of? (Think of their shape)
pyramidal
What does in vitro mean and how does it apply to studies in memory?
In vitro means that a study is performed in a test tube/culture dish.
Many times, in vitro studies are used to study the hippocampus.
What happens to the amount of time that a mouse spends searching the target quadrant in probe trials if its GluN1 subunit in the CA1 region is KOed?
The mouse would spend equal amounts of time in each quadrant.
What is an artifact in an fEPSP graph and what does it represent?
It is the part of the graph that results from a stimulating electrode current and it represents the opening of sodium channels.
Fill in the blank:
When stimulated an action potential travels down the perforant path and through the ______ _______ and eventually through the Schaffer collaterals.
Mossy Fibers
What is a fiber volley and what does it represent?
A Fiber Volley stems from stimulated axons that depolarize and it represents the action potential.
Which mouse in the Tonegawa experiment has the higher escape latency: the CA1 KO mouse or the control mouse?
the CA1 KO mouse
Design an experiment that tests whether a particular region in the hippocampus effects episodic/spatial learning.
answers vary