Sarcoid
This biopsy finding is considered the hallmark of sarcoidosis
What is non - caseating granuloma ?
Note: Non - caseating granulomas are also seen in Crohn's disease
This microorganism can result in a rheumatoid arthritis - like syndrome in adults
What is Parvovirus B19 ?
Rheumatoid arthritis + splenomegaly + neutropenia
What is Felty syndrome ?
Note: Caplan syndrome is RA + any pneumoconiosis
Two antibodies present in Sjogren's syndrome
What is Anti-Ro (SSA) antibodies & anti-La (SSB) antibodies ?
Also accept: Rheumatoid factor
Highly specific antibody found in SLE
What is anti-dsDNA antibody ?
Also accept: Anti-smith antibodies.
Note: ANA is highly sensitive for SLE (present in 98% of Pts). Anti-histone antibodies are found in drug induced lupus
Organ affected approximately 90% of the time in patients with sarcoidosis
What is lung ?
Note: The lung is almost always involved sarcoidosis. Bilateral hilar adenopathy is the classic CXR finding
Two antibodies present in rheumatoid arthritis
What is rheumatoid factor & anti - cyclic citrullinated antibodies ?
Also accept: Anti - CCP antibodies
This test should always be performed in patients with RA prior to surgery or intubation
What is cervical spine X ray ?
Note: Patients with RA can have atlantoaxial subluxation & subluxation of C1-C2
The best initial therapy for xerostomia in Sjogren's syndrome
What is water ?
Also accept: sugar-free lozenges/gum, pilocarpine, cevimeline
This commonly used anti - hypertensive agent is associated with drug induced lupus
What is hydralazine ?
Note: Isoniazid and procainamide are other major causes of drug induced SLE
List two laboratory values that might abnormal in sarcoidosis
What is elevated ACE level & hypercalcemia ?
Also accept: 1,25 dihydroxyvitamin d
Note: Hypercalcemia occurs as a result of 1a-hydroxylase activity of granulomas. Increased production of 1,25 dihydroxyvitamin D results in increased intestinal absorption of calcium
This medication slows/prevents structural progression of RA, preserves function, and decreases morbidity and mortality - it is considered the drug of choice in rheumatoid arthritis
What is methotrexate ?
The most common pulmonary manifestation of rheumatoid arthritis
What is pleural disease ?
Accept: pleural effusion, pleuritic chest pain, pleural friction rub
The most common renal manifestation of Sjogren's syndrome
Tubulointerstitial nephritis
Note: Other renal lesions seen in Sjogren's syndrome include RTA type 1, Nephrogenic DI
Medication class effective in decreasing dermatitis, arthritis, and fatigue & decreasing the accrual of tissue damage over time in systemic lupus erythematous
What is antimalarials ?
Also accept: hydroxychloroquine, chloroquine, quinacrine
Note: Hydroxychloroquine causes retinopathy. Eye exams are warranted every 6 months while on this medication.
A panniculitis seen in sarcoidosis characterized by painful subcutaneous nodules typically located on the pretibial surfaces
What is erythema nodosum ?
Note: anterior uveitis is the most common eye lesion associated with sarcoidosis
Deformity in which there is proximal interphalangeal joint flexion with distal interphalangeal joint hyperextension
What is Boutonniere deformity ?
Deformity in which there is hyperextension of the proximal interphalangeal joint and flexion of the distal interphalangeal joint
What is the swan neck deformity ?
One of the most dangerous complications of Sjogren's syndrome; usually detected incidentally after obtaining a labial (lip) biopsy
What is lymphoma ?
Note: lymphoma in sjogren's is of the low-grade marginal zone B cell type
List 4 skin lesions associated with SLE
What is malar rash, discoid rash, oral/nasal ulcers, UV light photosensitivity ?
Note: Also accept alopecia but realize it is not part of the clinical diagnostic criteria of SLE
In the USA, sarcoidosis is most often seen in African Americans; worldwide, it is this population that has the highest prevalence of sarcoidosis
What is the Nordic population ?
The three most frequently involved joints in rheumatoid arthritis
What is wrists, metacarpophalangeal joint (MCPs), and proximal interphalangeal joint (PIP)
Note: classically, the DIP is spared in RA
This lesion is considered to be pathognomonic for rheumatoid arthritis when present and histologically confirmed
What is rheumatoid nodules ?
During this test, a strip of filter paper is inserted into the eye at the lower eyelid and after several minutes the amount of moisture is measured
What is Schirmer's test ?
A deforming non-erosive arthropathy sometimes seen in SLE characterized by ulnar deviation of the 2nd to 5th fingers with metacarpophalangeal joint subluxation that is correctable or reducible with physical manipulation
What is Jaccoud arthropathy ?