Uveal Melanoma
This is the most common site for metastatic spread of uveal melanoma.
What is the liver?
This is the risk for a child of developing Rb if a parent has bilateral disease.
What is 45%?
This is the most common sign of leukemia in the eyes.
What is intraretinal hemorrhage?
Mutation in this gene accounts for the vast majority of retinoblastoma cases
RB1
The most common treatment for uveal melanoma?
What is radiation?
This tumor is found to coexist in a small percentage of patients with bilateral retinoblastoma.
What is pineoblastoma (trilateral disease)?
This systemic testing is indicated when vitreoretinal lymphoma is confirmed.
What is brain MRI and lumbar puncture?
Familial uveal melanoma has been most commonly associated with germline mutations in this gene.
What is BAP1?
What is congenital hypertrophy of the retinal pigment epithelium?
Subretinal fluid, orange pigment, & vision symptoms.
What are high risk features for melanoma?
Optic nerve invasion and choroidal invasion on pathological evaluation of an enucleated globe.
What are high risk features for metastasis of Rb?
When suspicious for lymphoma, tissue must be sent in this manner.
What is fresh for flow cytometry?
This gene expression profile result is associated with high risk for UM metastasis
What is Class 2?
This condition increases risk for UM to 1:400.
What is ocular melanocytosis?
This is the most effective treatment for vitreous seeding in Rb
What is intravitreal melphalan injection?
Intravitreal rituximab and methotrexate are commonly used to treat this disorder
What is primary intraocular lymphoma/vitreoretinal lymphoma?
In a patient with coexisting breast cancer and uveal melanoma, a germline mutation in this gene is most likely.
What is BRCA2?
This is the most common route for orbital spread of UM.
What is growth through scleral emissary canals?
This is the most common secondary tumor in retinoblastoma survivors.
What is osteosarcoma?
80% of these low-grade lymphomas are isolated and not associated with systemic disease.
What is conjunctival lymphoma? It’s a low-grade small B-cell lymphoma (MALToma).
Mutations in this gene occur in a high frequency in nevi of Ota, blue nevi, and uveal melanoma.
What is GNAQ?
What is RPE hamartoma associated with familial adenomatous polyposis? (RPEH-FAP)