Ela Ferrannini et al study
what was the objective of Ela ferrannini etal study
Study was done to evaluate the efficacy and safety ofdapagliflozin in treatment naive patients with type 2 diabetes.
what was the objective of Clifford Bailey etal study
Study was done to evaluate the efficacy and safety of dapagliflozin in patients who have inadequate glycemic control with metformin
what was the objective of R R henry etal study
To compare dapagliflozin plus metformin, dapagliflozin alone and metformin alone.
expalin the outcome of declare timi trial
•In the two primary efficacy analyses, dapagliflozin did not result in a lower rate of MACE. Dapagliflozin resulted in a lower rate of CV death or hospitalization for heart failure.
•Dapagliflozin showed a 36% Relative risk reduction in hHF(hospitalisation for Heart failure).
What was the objective of Verify trial
Do those with T2DM benefit from having combined therapy at the begining of their pharmacological treatment?
Explain the outcome of R R henry etal study
combination therapy (Dapa+Met) led to significantly greater reductions in HbA1c compared with either monotherapy.
Dapa 5 mg +metformin 1000mg showed a HbA1c Reduction of 2.05 whereas with Dapa 10mg + Met showed 1.98%
Summary of verify trial
ØAn early combination treatment strategy significantly reduced the relative risk of time to initial treatment failure by 49% vs initial monotherapy strategy
ØMedian time to failure was 3 years in the initial monotherapy strategy compared to over 5 years of early combination strategy
ØWhen all patients were receiving combination therapy the risk of time to second treatment failure reduced by 26%
Explain the outcome of Ela ferrannini etal study
Dapa 10 mg showed a mean HbA1c reduction of 0.89% compared to baseline at week 24 and 5 mg showed reduction of 0.77% in drug naïve T2DM
Explain the outcome of Clifford bailey etal study
As add on Metformin, Dapa 10 mg showed a reduction in Mean HbA1C by 0.84% compared to baseline at week 24 and Dapa 5mg showed a reduction of 0.70%.