CVOT
What is the mean baseline A1C in the REWIND Trial?
7.3%
Describe/set up the Trulicity patient?
She is frustrated her current therapy isn’t enough, A1C between 8-10% and CV risk factors. She is anxious about what is next and the more the next medication requires her to do the less likely she is to do it. She needs motivation now.
Trulicity is indicated as an?
Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes
What are the names of Erica”s children?
Nora and Zachary
Doctor states: Ozempic has better weight loss...
Is this something you are seeing or hearing?As you know, neither Trulicity nor Ozempic are indicated for weight loss. Would you agree that the amount of weight a patient loses may depend on a number of factors? Clarify, Address and Expand with date and bring it back to the patient
What was the ___% risk reduction of MACE-3 in the REWIND Trial
12%
Trulicity is unique and targets both____ and _____. Reductions can be seen within_____hrs after the first dose.
Fastings and postprandials and 48 hrs
In a subset analysis patients had a baseline A1C>8.5% what was the A1C reduction and how many weeks was the study?
2.1 reduction in A1C
26 weeks
What state did Maggie do her volunteer work in the Peace Corps?
Texas
Doctor: I think CV benefits are a class effect...
Is this something you are seeing or hearing? I want to remind you that Trulicity CVOT, Rewind trial was designed differently then any other GLP-1 CVOT. Rewind is the first and only GLP-1 RA CVOT to Include a majority of patients without established CVD. EVen with the majority of primary prevention patient population, Trulicity showed a significant reduction in MACE 3, 12% RR across primary and secondary prevention patients
How is the Trulicity CVOT Rewind trial designed differently than any other CVOT trial?
Rewind is the only GLP1 RA CVOT to include A majority of patients without established CVD.
Trulicity is the only GLP1 RA that provides these 3 benefits together?
Powerful A1C reduction, simply delivered and CV benefit in both Primary and Secondary prevention patients
The AWARD___ was the study of once weekly Trulicity in combination with basal insulin?
AWARD 9
What is Terrys favorite football team?
Colts
Doctor: My patients would prefer an oral like Rybelsus...
Doctor its great you have options for your patient, but lets think about that patient that is frustrated their current therapy isn’t enough...The more the next medications requires them to do the less likely they are to do it. Trulicity offers powerful efficacy with once a week dosing. Show 48 hr data And no strict dosing requirements. They can take trulicity once a week any time of day with or with out food and with their other medication. How would ease of use and The dosing Of Trulicity make that patient feel who is already frustrated?
What was the median follow up time in years in the REWIND Trial and why?
5.4 years It was event driven and patients were assessed every 6 months until 1200 confirmed primary outcomes had occurred
Trulicity may be stored at room temperature for up to______ days?
14 days
In addition to glycemic control and Powerful efficacy, what are some other motivating factors that could help the patient start and stay on therapy?
Once a week
The pen that patients preferred
Possible weight lose
In lieu of running the Boston Marathon Lindsay did what good deed?
Gave Blood
Doctor: 12% risk reduction is not as impressive as Ozempic 26% reduction....
I want to remind you that the Trulicity CVOT, REWIND was designed differently then any other GLP-1 CVOT. The majority of patients in REWIND had risk factors, but did not have established CVOT. LIke you stated early that primary prevention population of 68% was similar To what you see in your current practice. REWIND showed a 12% risk reduction in MACE-3 including both primary and secondary patient populations.
What does number to treat mean? What was the Number Needed to treat in the REWIND Trial?
Number of patients treated to prevent 1 adverse event. Primary prevention patients Number to treat was 60 and 18 in secondary prevention Patients.
Trulicity acts like the natural human hormone GLP-1, helping the body do what its suppose to do naturally. What are the 3 things?
Slows down gastric emptying
Reduces hepatic glucose production by decreasing glucagon secretion
Glucose dependent insulin secretion
Patients saw a ____% A1C reduction with Trulicity 1.5mg as the only add-on to metformin?
1.4% reduction
What college did Molly go to?
UMASS
Doctor: I feel like your two products, Jardiance and Trulicity are competing against each other now that they both have a CV indication....
Its great that you have so many options for your patients and you know your patients best. Let’s talk about 2 patients you may see here in your office today... Set up the patient....and you can always add Trulicity onto Jardiance, they can be used together.