Alcoholic liver disease
End result of chronic liver diseases
What is Cirrhosis?
Lifestyle modification including weight loss can reverse liver damage
What is the treatment of NAFLD?
Accumulation of ferritin systemically
What is Hemosiderosis?
Hemochromatosis is also known by this name
What is bronze diabetes?
Mutation of this gene results in Wilson disease
What is the ATPB7 gene?
Leading cause of liver cirrhosis in the United States
What is chronic alcoholism?
Triglyceride build up in the liver that is not caused by alcohol use
What is nonalcoholic hepatic steatosis?
Hemochromatosis is this kind of inherited disease
What is autosomal recessive?
Gender experiencing hemochromatosis earlier
What are men because of blood loss in women during menstruation
Dark rings that appear to encircle the iris of the eye
What are the Kayser–Fleischer rings?
Reversible stages of alcoholic liver disease
What are hepatic steatosis and steatohepatitis?
AST : ALT <1
What is the ratio of AST to ALT in NAFLD?
Removing blood from your body on a regular basis to treat hemochromatosis
What is phlebotomy?
Who should be screened for hemochromatosis?
What are the first-degree family members of those with hemochromatosis
Excess deposition of copper here leads to neurological symptoms
What are the basal ganglia?
AST:ALT > 2:1
What is the ratio of AST to ALT in the alcoholic liver disease?
Damaged cytokeratin filaments in the cytoplasm
What are the Mallory bodies?
This gene regulates the production of hepcidin
What is the HFE gene?
These are the late manifestations of hemochromatosis
What are diabetes mellitus, cardiomyopathy, arthropathy, hepatic dysfunction, ED, and hyperpigmentation of the skin
This drug is used to chelate copper
What is D-penicillamine?
Promotes triglyceride synthesis in the liver leading to hepatic steatosis
What is the consequence of an increase in the NADH to NAD ratio?
Used to stain collagen to detect fibrosis
What is the trichrome stain?
The classic triad of hemochromatosis
What are cirrhosis, diabetes mellitus, and skin pigmentation?
Common mutations in the HFE gene causing hemochromatosis
What are C282Y (cysteine-to-tyrosine substitution at amino acid 282) and H63D (histidine-to-aspartic acid substitution at amino acid 63)
The inheritance pattern of Wilson's disease
What is autosomal recessive disorder?