Clinical Manifestations
An uncommon type of memory disorder that causes issues with behavior and language
What is frontotemporal dementia?
A condition that results from the reduction in glutamate absorption at the synaptic cleft, dysfunction of astrocytic EAAT2, and activation of calcium-dependent enzymatic pathways
What is neurodegeneration?
Caused by mutations in the SOD1 gene
Is genetics a factor?
Medication with the common brand of Rilutek used to treat neurodegenerative disorders
What is Riluzole?
This is the name of the process in this disease where there is excessive exposure to a neurotransmitter called glutamate that causes a constant stimulation of neurons
What is excitotoxicity? Or what is glutamate excitotoxicity?
Speech disorder where the muscles can no longer produce speech
What is dysarthria?
These cells produce cytokines that cause inflammation which can lead to neural death
What are microglia 1 phenotype cells? Or what is microglia 1?
Exposure to toxic or infectious agents, viruses, diet, and physical trauma are possible reasons for this disorder.
What are some environmental factors?
Some medications given inhibit the action of a neurotransmitter glutamate
What medication is given?
What genes undergo a mutation that can cause over-accumulation of dysfunctional proteins?
What is C9orf72 gene, SOD1 gene, TARBP gene, and or FUS gene?
The name of the symptom that causes muscle twitches and progressive abnormal muscle stiffness
What is muscle spasticity?
These cells usually help support motor neurons, neuron metabolism, and maintain the central nervous system’s homeostasis. They become dysfunctional in this disease.
What are astrocytes?
This disorder can be tested using EMG, NCS, MRI, blood/urine testing, and muscle biopsies.
What tests are done to diagnose this disorder?
A machine that helps one intake oxygen and exhales carbon dioxide
What is a mechanical ventilator, ventilator, respirator, or breathing machine?
Can strike at any time but is most common in ages 55 to 75
What age is most affected?
When a patient loses the ability to control all four limbs
What is quadriplegic?
This is the site of impulse signaling between the nerve terminals and muscle fibers. In this disease, an impulse signal cannot get passed to this site
What is the neuromuscular junction?
Individuals experience muscle cramps, muscle twitching, slurred speech, and muscle tightness.
What are the symptoms of this disorder?
A long lasting disorder that does not have a cure
What is an incurable chronic illness?
World renowned English theoretical physicist, cosmologist, author, and mathematics professor at the University of Cambridge had this disease. A movie called, “The Theory of Everything” was created as a biography of his life.
Who is Steven Hawkings?
The lasting effect of dying neurons in both the upper and lower nervous system leads to?
What is paralysis?
The movement of muscles is controlled by this system and is affected by this disease.
What is the nervous system? Or what is the central nervous system or CNS?
Men are more susceptible to this disorder than women
What gender is most affected?
Physical therapy is done to restore strength
What physical treatment is done?
The Ice Bucket Challenge was done in 2014 for disorder awareness and to encourage donations for research
What was the internet challenge for this disorder?