ASCs
True/False: Adult stem cells are easy to isolate
False
A primary layer of cells that forms during embryonic development
germ layer
Signaling pathway responsible for ASC homeostasis and TAC proliferation
Wnt signaling
A disease potentially curable with PSC-derivatives
Alzheimer's disease
The ability of stem cells to replicate themselves by dividing into the same non-specialized cell type over long periods
What is self-renewal
ASC hierarchy with analogy to war
The battlefiled concept
Fertilized egg
Zygote
Three features characteristic of a stem cell niche
Soluble signals, Adhesion, Spindle orientation
The source for embryonic stem cells
blastocyst
The process by which dividing, unspecialized cells are equipped to perform specific functions
What is differentiation?
Ribonucleotide analog used to trace ASCs
BrdU
Process that establishes the three germ layers
Gastrulation
Prime effector of the Wnt signaling pathway
beta-catenin
Benign tissue mass that PSCs form in vivo
Teratoma
Two potential uses of stem cells
Toxicity testing and Understanding development
A subpopulation of the proliferative compartment
Transit amplifying cell
Outer cell layer of the blastocyst
Trophoectoderm
Special location within the intestinal stem cell niche where stem cells reside that respond to injury
Position 4
Researcher who identified/isolated mouse ESCs for the first time
Gail Martin, Martin Evans, Matthew Kaufman
Different types of stems cells have varying degrees of this mightiness
Potency
Another name for adult stem cell
Somatic stem cell
Two immediate structures (tissues) that the inner cell mass gives rise to
Epiblast and hypoblast
Intracellular kinase that responds to a non-canonical Wnt
JNK
Two molecular differences that characterize naive pluripotent stem cells
Tfcp2l1, oxidative phosphorylation
The only cell that can give rise to a complete new organism
What is a totipotent cell?