BTKi'S
This is the only non-covalent BTKI currently approved
Pirtobrutinib
What is the brand name for Pirtobrutinib
Jaypirca
What does GO BEYOND mean to you?
Amazing answer!!
Secondary malignacies, including non-skin cancers, occured in how many patients
9%
What is the incidence of clinical TLS in CLL14
0%
Which BTKi was the first approved for use in CLL
Ibrutinib
What is the recommended starting dose of Pirtobrutinib
200 mg once daily
What is our goal in CLL?
Win in 1st line; maintain 2L+ market share
In the Bruin trial, fatal adverse events occurred in what percentage of pts
11%
In CLL 14, what was the median duration of exposure to Ven
10.5 months
What is the name of the study that was responsible for Pirto approval
Bruin
What generation BTKi is Pirtobrutinib
3rd
What is your favorite ISA slide?
Great answer
Grade 3 or 4 atrial fibrillation or flutter occurred in what percent of pts
1.5%
In CLL 14, what percentage of pts needed to be dose reduced d/t adverse reactions
21%
How many days prior to and after surgery do pts need to hold BTki
3 to 7 depending on type of surgery/risk
In the Bruin trial, what percent of patients discontinued Pirtobrutinib
2%
What is an example of a powerful question when starting a call?
Outliers rule!!!
Major hemorrhage occurred in what percent of patients
3%
In CLL 14, what percentage of pts experinced any grade of URI
17%
In CLL, which is constantly being signaled
BCR - b cell receptor pathway
Pirtobrutinib is indicated for patients after how many lines of therapy
At least 2 lines of therapy including BTKi and BCL2 inhibtor
What does "A, B, C" stand for
Activate, Build, Customize
In pts with CLL/SLL, grade 3 or higher infections occurred in how many patients and what percentage resulted in death
32% and 8%
41%