X-Treme Genetics
Fragile X syndrome is characterized by this type of inheritance pattern, where the gene mutation is carried on the X chromosome.
What is X-linked recessive inheritance?
Down syndrome is caused by an extra copy of this chromosome.
What is chromosome 21?
This type of cell can be generated from adult cells and reprogrammed to an embryonic-like state.
What are induced pluripotent stem cells (iPSCs)?
This type of footwear is required in the lab to protect your feet from spills and dropped objects.
What are closed-toe shoes?
PCR stands for this technique used to amplify DNA segments
What is polymerase chain reaction
The mutation in fragile X syndrome affects the production of this protein, crucial for normal brain development.
What is the FMR1 protein?
This law states that alleles segregate independently of each other during gamete formation.
What is the Law of Independent Assortment?
These complex 3D models can integrate multiple organ systems, such as brain and spinal cord tissues.
What are assembloids?
This piece of safety equipment is used to protect your eyes from chemical splashes.
What are safety goggles?
During gel electrophoresis, DNA fragments move towards this charged electrode.
What is the positive electrode (anode)?
The number of CGG repeats it takes for Fragile X to be fully expressed.
What is 200?
This technique allows precise editing of DNA sequences within the genome and has revolutionized biomedical research and potential therapeutic applications.
What is CRISPR-Cas9?
This cutting-edge technique allows for the precise manipulation of organoid genomes to study gene function and disease mechanisms.
What is CRISPR-Cas9 gene editing?
When handling volatile chemicals, this type of laboratory equipment provides ventilation to limit exposure to hazardous fumes.
What is a fume hood?
The initial step of PCR, where the double-stranded DNA is heated to separate into two single strands, is called this.
What is denaturation?
The expansion of CGG repeats in the FMR1 gene leads to this epigenetic modification, which silences the gene and reduces production of the FMR1 protein.
What is DNA methylation?
These are the pyrimidines of RNA.
What are Cytosine and Uracil?
This technique allows for the growth of organoids under conditions that mimic the physiological environment of the human body, including factors such as mechanical forces and fluid flow.
What is bioreactor technology?
This document provides detailed information on the hazards of chemicals used in the lab
What is a Safety Data Sheet (SDS)?
This step of PCR involves cooling the reaction to allow primers to bind to their complementary sequences on the template DNA
What is annealing?
This scientist is making great discoveries in Fragile X and is an inspiration to thousands to millions including 25 high school students.
Who is Dr. Emily Graves Allen?
This mathematical model predicts the distribution of genotypes in a population under the assumptions of random mating, large population size, and absence of selection.
What is the Hardy-Weinberg equilibrium?
Assembloids are being used to model the complex immune responses and neurodegenerative aspects of this autoimmune disease.
What is multiple sclerosis?
To minimize contamination and infection risk, this level of biosafety is required when working with agents that pose a moderate hazard to personnel and the environment.
What is Biosafety Level 2 (BSL-2)?
This method combines gel electrophoresis with a membrane transfer technique to detect specific DNA sequences.
What is Southern blotting?