Introduction
More than 40% of this group experiences an influenza illness every year.
Who are pre-school aged children?
The strain used of RSV-A and Influenza A
Memphis 37 and Wisconsin/67/2007
Both viral load and this other measurement of illness severity increased together during RSV and influenza infections.
What is symptom score?
Figure 2: According to this graph, RSV infection produced significantly more of this measurable outcome compared to influenza.
What is nasal mucus?
Influenza antivirals are most effective when administered within this time frame after symptom onset.
What is 36-48 hours?
Nearly 100% of children become infected with this virus by the time they are three years old, according to the introduction.
What is RSV?
These numbers of participants were intranasally inoculated with RSV-A and influenza A, respectively.
What are 20 and 17?
Of the volunteers infected with RSV, this percentage met the study’s infection criteria.
What is 50% or 10/20?
In figure 1, influenza illness severity based on symptom scores increases after this event.
What is peak viral load?
One reason for the lack of RSV antivirals is the uncertainty about whether reducing RSV viral load would lead to this.
What is clinical benefit (or disease reduction)?
This kind of study involving volunteers provides valuable data but may not fully generalize to the broader population.
What is a Human challenge model or volunteer challenge study?
Nasal washes were collected for viral load quantification using this type of assay for RSV.
What is a plaque assay?
In this study, RSV produced significantly more of this physical illness marker compared to influenza.
What is nasal mucus?
Figure 1. This day is when RSV symptom scores and viral load both peaked
What is day 6?
The discussion highlights that for influenza, the earlier an antiviral is given, the greater the reduction in this measure.
What is viral load?
The objective of the report is to do two things.
What is viral dynamics and timing of clinical illness?
The study excluded participants with these two pre-existing conditions, to reduce the risk of confounding factors in the results.
What are asthma and chronic sinusitis?
The study revealed that both RSV and influenza infections showed increases in viral load and disease severity together, but this virus showed more delayed symptoms.
What is RSV?
In figure 1, influenza viral load starts declining after this day, while symptom score continues to increase for another day.
The authors discuss that one limitation of the study is the generalizability of results to the larger population, as the study primarily used this group of volunteers.
Who are young adults?
This antiviral drug, effective for treating influenza, reduces viral replication when given early in the course of the infection.
What is oseltamivir?
The volunteers in the RSV group were quarantined for 12 days, while the influenza group was quarantined for this shorter duration.
What is 7 days?
RSV viral load and illness peaked together on day 5.4, but peak RSV disease severity occurred on this day.
What is day 6.2?
Figure 2. indicates that RSV nasal mucus production is significantly higher compared to influenza, with this approximate daily weight of mucus production at its peak.
What is 35 grams?
The study suggests that the potential time window for effective antiviral therapy for RSV may be longer than this for influenza because of this reason.
What is a slower viral replication and disease progression in RSV?