Disorder of White Blood Cells
Exposure to Carcinogens, genetics, Leukemia, Lymphoma, normal cells proliferate, enlarged lymph nodes/spleen, tiredness, feeling of fullness, fever, chills
What is change in function of cells?
many different causes(acute blood loss), RBCs are destroyed prematurely, RAAS is activated, hypoxia in tissue, significant blood loss, pale, high reticulocyte count on CBC
What is anemia?
acute most common in children following a viral infection, chronic form in adults, body develops antibodies against its own platelets, spleen enlargement, corticosteroids, platelet transfusions
What is Immune Thrombocytopenic Purpura?
elevated lipids in bloodstream, atherosclerosis, diabetes and hyperthyroidism, LDLs are ingested by microphages, generally not reported or report angina, xantoma, blood tests, lifestyle changes
What is Hyperlipidemia?
Thrombus develops, Virchow's Triad, area of inflammation in the vein-travels through venous system, edema, D-dimer test
What is Deep Vein Thrombosis?
Most common Leukemia in children, precursors to T and B lymphocytes, vague symptoms, chemotherapy is most common
What is Acute Lymphoblastic Leukemia?
loss of RBCs-iron deficiency, signs of anemia, blood tests for Fe++ levels, investigate GI bleeds, address source of bleeding
What is chronic blood loss?
Hemophilia A and B, recessive genetic disorders, disruption of the intrinsic pathway of coagulation, spontaneous bleeding into a joint space, CBC, coagulation studies
What is Hemophilia?
elevated BP, primary(unknown cause), exerts high forces on endothelial linings of vessels, effects organs, need acurate blood pressure, 2 stages, medication may help
What is Hypertension?
Damage to valves in deep veins of legs, pooling of blood due to damaged valves, can cause edema, thinning hair, spider veins, Venous Doppler ultrasonography, compression stockings
most common aggressive leukemia, proliferation of undifferenetiated WBCs, signs of infection, fatigue, weakness, 2 phases of chemotherapy
What is Acute Myelogenous Leukemia?
Erythtocyte destruction outpaces production, signs and symptoms of anemia, jaundice, dark urine, enlarged spleen, reticulocyte count elevated, damaged RBCs, immunosuppressant drugs
What is Hemolytic blood loss?
autosomal genetic mutation, vWF, susceptible to bleeding/hemorrhage, affects factor VIII, unexplained bruising, prolonged aPTT, lifestyle changes, test vWF levels
What is von Willebrand Disease?
build up of fats and cholesterol on arterial walls, older males of African descent, plaque begins to form on lining, macrophages ingest large quantities of LDLs and become foam cells, typically no symptoms until organ damages, treatment usually same as hyperlipidemia
What is Atherosclerosis?
abnormally dilated superficial vein, more common in females, incompetent valves, blood blockflow, visual exam, duplex ultrasound for diagnosissurgery to remove varicose veins
What is Vasicose Veins?
most common in middle-aged adults, B Cells are affected but can also affect T cells and NK cells, enlarged lymph nodes, diagnostic tool is lymph node biopsy
What is Non-Hodgkin's Lymphoma?
arterial dysfunction and reduced blood flow to extremities, intermittent claudication, ischemia, signs and symptoms of atherosclerosis, blood tests
What is Peripheral Arterial Disease (PAD)?
most common lymphoma in adolescent and young adults, exact cause unknown, Reed-Sternberg Cells, enlarged lymph node, biopsy diagnosis
What is Hodgkin's Lymphoma?