Proton Pump Inhibitors
How are the prodrug forms of PPIs activated?
What is by the acidic environment of the stomach?
What group was used to replace the thiourea group in cimetidine to reduce toxicity?
What is the cyanoguanidine group?
Which witch? This Sanderson sister can be identified by her bright red hair and iconic green clothing.
Who is Winifred "Winnie" Sanderson?
H1 or H2? Which receptor is responsible for the production of gastric acid?
What is an H2 receptor?
For 4-methylhistamine, one conformation was highly favored, what concept is responsible for this?
What is steric hindrance?
Give one reason PPIs are replacing H2 antagonists
What is their superior efficacy in reducing stomach acid, their effectiveness in treating ulcers caused by NSAIDs, or their ability to treat H. pylori infections?
What was the brand name under which cimetidine was marketed?
What is Tagament?
What dance was allegedly a "graveyard smash" that "caught on in a flash"?
What is The Monster Mash?
H1 or H2? Which type of receptor was not believed to exist until the 1970s?
What is the H2 receptor?
What compound's discovery marked the first histamine antagonist with partial agonist activity?
What is N-guanylhistamine?
What do PPIs do in parietal cells?
What is they irreversibly inhibit the H+/K+ gradient in parietal cells, blocking the final step in gastric acid secretion
What was the major issue with burimamide as an H2 receptor antagonist?
What is its lack of potency?
Which U.S president told a group of schoolkids that the white house was haunted by the ghost of Abraham Lincoln?
Who is George H. W. Bush?
What type of histamine receptor contains only two binding sites?
What is a H1 receptor?
What functional group was associated with toxic effects in the creation of metiamide?
What is a thiourea group?
Along with PPIs, what two other things are used in the treatment of H. pylori?
What are two antibiotics?
Cimetidine was found to block the effects of what stimulator of gastric acid release?
What is pentagastrin?
According to the Sheb Wooley song lyric, this creature is a “One-eyed, one-horned, flyin’…” what?
What is a "purple people eater"?
What type of bonding is associated with H2 receptors?
What is hydrogen bonding?
In the production of burimamide from SKF 91581, scientists added a methyl group and what other structural feature?
What is 4-carbon linker?
For an effective PPI, the drugs need to be stable enough to survive the journey in the blood stream, but reactive enough to...
What is undergo acid-catalyzed interconversion in the parietal cell?
Ranitidine differed structurally from cimetidine due its furan ring and the addition of what functional group?
What is a nitrokenteneaminal group?
Approximately how much money did Americans spend on candy in 2023?
What is 3.6 billion?
From the SAR studies, it was found that H2 antagonists required a positively charged nitrogen, an amidine unit in the ring, and what other structural feature?
What is a flexible chain connecting the ring and cation?
When beginning with no lead or target compounds, what compound was used by scientists to begin the development of H2 antagonists?