Cell Injury
Ischemia
What is the mechanism of cell injury called when there is decreased blow flow to the cell?
Fibronectin, proteoglycans and elastin, collagen, and parenchymal (organ) and endothelial (skin) cells
What are the components tissue healing processes influenced by?
the stress is sufficiently small in magnitude or short enough in duration that the cell is able to recover homeostasis after removal of the stress
What is reversable or sublethal cell injury?
bacteria, viruses, mycoplasmas, fungi, protozoa
What is the mechanism of Cell Injury called for infectious agents?
Formation of the scaffold, tensile strength and substances that glue the cells together.
What is fibronectin?
Atrophy, hypertrophy, hyperplasia, metaplasia, and dysplasia
What are common cellular adaptions to cell injury?
mitochondria, ribosomes, cell membranes
What are the various components of cells subject to changes by aging?
Bind to fibronectin and to collagen to help stabilize tissue undergoing repair & retain water and aid in hydration of tissue being repaired
What are proteoglycans and elastin responsible for?
cell death or necrosis
What occurs when the is unable to adapt and the cell injury is irreversible?
Resistance to infection, pathologic issues such as atherosclerosis.
What are some age related changes caused by atrophy of tissues or organs?
a carbohydrate chain of proteins that becomes cross-linked to form fibrils or long sheets that provide tissues with elasticity
What does fibroblasts synthesize and elastin secrete?
Function in an altered environment avoiding injury
What does adaptation enable the cell to do?
mitochondrial disorders, downs syndrome, or any alteration in chromosomal structures
What are some genetic aspect of diseases?
signaling molecules that regulate cellular responses during tissue repair and wound healing
How is the function of Growth Factors?
Vascular supply, nutrition, diagnoses with decreased O2 perfusion, DM, prolonged use of corticosteroids, neurological impairment
What are factors affecting cellular healing?