Allergy and Immunology
Urticaria pigmentosa, recurrent anaphylaxis, and elevated tryptase level
Mastocytosis (also accept cutaneous mastocytosis)
Involvement of this joint by osteoarthritis gives a 'squared appearance' to the base of the thumb
First carpometacarpal
Parasitic disease whose name derives from the Italian 'bad air'
Malaria
Field of research that studies how genes affect a person’s response to drugs
Pharmacogenomics (accept Pharmacogenetics)
Most common cause of acute cyanide toxicity in industrialized countries
Domestic fires (accept smoke inhalation)
The only FDA-approved long-acting muscarinic antagonist to treat asthma
Tiotropium bromide (accept tiotropium or Spiriva)
Bone disease due to compromise of bone vasculature leading to bone death and mechanical failure
Osteonecrosis (aseptic necrosis, avascular necrosis, atraumatic necrosis, and ischemic necrosis)
German physician credited for the discovery of the causative organism for tuberculosis
Robert Koch
The likelihood a genotype will manifest as phenotype
Penetrance
Clinical condition resulting from excessive oxidation of heme iron to the ferric state
Methemoglobinemia
Resin found in poison ivy and mango peel that causes dermatitis
Urushiol
Syndrome of neck pain associated with calcium phosphate deposition disease and atlantoaxial joint calcifications on radiography
Crowned dens syndrome
Organism ingested by internist Barry Marshall to prove its infectivity and association with disease
Helicobacter pylori
Most common HFE gene mutation
C282Y (accept Cysteine-282-Tyrosine)
Receptor competitively inhibited by flumazenil
Gamma-amino-butyric-acid (accept GABA)
Gas used to diagnose asthma by measuring fractional excretion
Nitric oxide
Class of biological agents most commonly associated with drug-induced lupus
Tumor necrosis factor antagonists (accept TNF antagonists)
Physician credited with first describing digital clubbing
Hippocrates (also known as Hippocratic fingers or nails; considered the oldest sign in clinical medicine)
Autosomal recessive disorder caused by a HEXA gene mutation
Tay-Sachs disease
Argyria refers to toxicity caused by this substance
Silver
Hypersensitivity reaction caused by administration of nonhuman sera or foreign proteins
Type III hypersensitivity reaction (accept immune complex-dependent reaction or serum sickness)
Disease in which presence of the melanoma differentiation-associated gene 5 antibody is associated with rapidly progressive interstitial lung disease
Dermatomyositis
Infectious disease prevention practice named for the Italian words meaning 40 days
Quarantine (quaranta giorni - holding arriving ships at anchor for 40 days before landing)
Gene that encodes the cytochrome P450 enzyme involved in the metabolism of clopidogrel
CYP2C19
Neurologic injury due to excessive use of inhaled nitrous oxide is caused by inactivation of this vitamin
B12 (accept cyanocobalamin)