Physio
What is the neurotransmitter released at the neuromuscular junction?
Acetylcholine (ACh)
This type of muscle weakness is the most common initial symptom is Myasthenia Gravis
Ocular or eye weakness
Ptosis
Diplopia
Myasthenia gravis is considered uncommon, but not ultra-rare. Globally, how many people per 100,000 are estimated to have this disease? (+/- 20% of the answer will be considered correct already)
12 people per 100k
What local depolarization occurs on the motor end plate when ACh binds its receptors?
End-plate potential (EPP)
What is the most feared, life-threatening complication of Myasthenia Gravis, where respiratory muscles (diaphragm and chest muscles) become too weak to support breathing, and require emergency care?
Myasthenic Crisis
This specific public health concern, where certain drugs can worsen Myasthenia Gravis or trigger a crisis, is described as "highly preventable" with the use of EHR/pharmacy alerts and prescriber education. What is it?
Unsafe medication
This event, triggered by Pi release, is the conformational change that pulls actin toward the M-line.
Power stroke
For myasthenia gravis to take effect in neuromuscular signaling, ___ from _ cells binds to the nicotinic acetylcholine receptors.
Autoantibodies from B Cells
Which burden of Myasthenia Gravis is related to the broad aspect of well-being, leading to work and activity impairment?
Quality of life
What is the repeating contractile unit of a muscle fiber?
Sarcomere
This is the most distinguishing clinical feature of Myasthenia Gravis: characterized by fluctuating muscle weakness that worsens with activity, and improves with rest?
Fatiguability
What is the estimated financial burden for a single Myasthenia Gravis flare-up in the U.S., due to the need for specialized equipment, including ICU stays and procedures? (In USD; guesses that fall within the range will be considered)
$26,000 to $51,000