Randomized controlled trials involving assertive community treatment (ACT) have most consistently shown improvements in:
(A) Substance use
(B) Arrests or jail time
(C) Psychiatric symptoms
(D) Medication adherence
(E) Psychiatric hospitalization
D - medication adherence
Emil Kraepelin is credited with being the first to separate senile dementia from dementia praecox, which has since become known as:
(A) Delirium
(B) Schizophrenia
(C) Alzheimer disease
(D) Lewy body dementia
(E) Major depressive disorder
B - Schizophrenia
Which of the following conditions is d/t an autosomal dominant genetic abnormality?
(A) Wilson's disease
(B) Sickle cell anemia
(C) Klinefelter syndrome
(D) Cri-du-Chat syndrome
(E) Huntington's disease
E - Huntington's disease
(A) Interpersonal therapy
(B) Psychodynamic therapy
(C) DBT
(D) CBT
(E) Motivational enhancement therapy
A - Interpersonal therapy
Which of the following neurotransmitters plays a key role in regulating the transition between sleep and wakefulness?
(A) Choline
(B) Serotonin
(C) Histamine
(D) Glutamate
(E) Anandamide
Which of the following brain regions is most commonly targeted with rTMS to treat MDD?
(A) orbitofrontal cortex
(B) Dorsolateral prefrontal cortex
(C) Dorsomedial prefrontal cortex
(D) Ventrolateral prefrontal cortex
(E) Ventromedial prefrontal cortex
B - dorsolateral prefrontal cortex
The psychiatric disorder most closely linked to accelerated brain growth between the ages of one and four years is ...
(A) Major depressive disorder
(B) Tourette's disorder
(C) Psychotic disorder
(D) Autism spectrum disorder
(E) ADHD
D - Autism spectrum disorder
Which of the following syndromes is d/t binding of methyl CpG protein 2 to methylated DNA?
(A) Rett
(B) Fragile X
(C) Angelman
(D) Coffin-Lowry
(E) Rubinstein-Taybi
A - Rett
In cognitive theory, what are the results, assumptions, and attitudes that guide a person's interpretation of others and themselves?
(A) Core beliefs
(B) Simple schemas
(C) Automatic thoughts
(D) Intermediary beliefs
(E) Compensatory strategies
D - Intermediary beliefs
Orexin neurons involved in the regulation of appetite arise from which part of the hypothalamus?
(A) Lateral
(B) Ventromedial
(C) Arcuate nucleus
(D) Median eminence
(E) Paraventricular nucleus
A - Lateral
There is an increased risk of schizophrenia diagnosis in the relatives of patients with which of the following personality disorders?
(A) Antisocial
(B) Avoidant
(C) Paranoid
(D) Schizoid
(E) Schizotypal
E - Schizotypal
Which of the following cognitive changes is most commonly associated w/ perimenopause?
(A) Decline in numeric reason
(B) Diminished visuospatial abilities
(C) Perceived loss of problem-solving skills
(D) Subjective worsening of verbal memory
(E) Abnormalities in objective memory testing
D - Subjective worsening of verbal memory
Which potentially fatal condition can be caused by mutations in the branched-chain alpha-keto acid dehydrogenase complex?
(A) PKU
(B) Gaucher disease
(C) Tay-Sachs disease
(D) Maple syrup urine disease
(E) X-linked adrenoleukodystrophy
D - Maple syrup urine disease
The negative therapeutic reaction in psychodynamic psychotherapy refers to which of the following?
(A) The patient systematically attacks and devalues the therapist
(B) The therapist reacts negatively to the patient's efforts to engage the therapist in helping the patient
(C) The patient gets worse in response to therapist interpretations that are accurate and appropriate
(D) The amelioration of a patient's presenting smyptom leads to substitution of another symptom
(E) The therapist is feeling depressed as the patient prepares for termination of therapy
C - The patient gets worse in response to therapist interpretations that are accurate and appropriate
A Patient w/ Alzheimer disease is started on donepezil, but discontinues it d/t profound nausea and dizziness. Which of the following concurrently prescribed medications would most likely be responsible for this reaction?
(A) Lithium
(B) Phenytoin
(C) Fluoxetine
(D) Gabapentin
(E) Risperidone
C - Fluoxetine
Which of the following medications for alcohol use disorder could be contraindicated in a patient with decompensated cirrhosis?
(A) Baclofen
(B) Pregabalin
(C) Naltrexone
(D) Gabapentin
(E) Acamprosate
C - Naltrexone
(A) Reduced neuronal density
(B) Reduced number of neurons
(C) Increased gray matter volume
(D) Reduced dendritic spine density
(E) Increased pyramidal somal cell volumes
D - Reduced dendritic spine density
A patient presents with symptoms of psychosis, apathy, intermittent abdominal pain, neuropathy and autonomic dysfunction. Which of the following would be the next best step for diagnosis?
(A) Urine test for porphobilinogen
(B) serum electrolytes for albumin
(C) Liver function tests for alkaline phosphatase
(D) MRI for a mass lesion
(E) CT scan for intracranial bleeding
A - Serum test for porphobilinogen
Which of the following psychotherapies is considered first line in the treatment of adolescents suffering from anorexia nervosa?
(A) Group
(B) Supportive
(C) Interpersonal
(D) Family-based
(E) Psychodynamic
D - Family-based
Which of the following neuropeptide neurotransmitters has been most implicated in the pathogenesis of schizophrenia spectrum disorders?
(A) Apelin
(B) Oxytocin
(C) Prolactin
(D) Calcitonin
(E) Neurotensin
E - Neurotensin
The anti-manic properties of tamoxifen are thought to be due to its inhibition of which of the following?
(A) Protein kinase A
(B) Protein kinase C
(C) Inositol triphosphate
(D) Glutamic acid decarboxylase
(E) VG Na channels
B - Protein kinase C
Prenatal infection with which of the following has the most evidence for the risk of developing schizophrenia?
(A) Rubella
(B) Borna disease
(C) Epstein-Barr virus
(D) Influenza
(E) RSV
D - Influenza
A woman is psychiatrically hospitalized with prominent paranoid delusions, auditory hallucinations, and progressive mood lability. She subsequently develops waxing and waning confusion, word-finding difficulty, and periods of mutism. An EEG detects extreme delta brushing. Anti-NMDA receptor antibody testing is positive. Which of the following neoplasms is most likely to be detected on further testing?
(A) Melanoma
(B) Thymoma
(C) Ovarian teratoma
(D) Hodgkin lymphoma
(E) Small cell lung cancer
C - ovarian teratoma
In object relations theory, internal objects are best understood as which of the following?
(A) Idealized ego representation
(B) Unconscious defense mechanisms
(C) Innate drives to satisfy one's needs
(D) Psychic representations of external entities
(E) The product of the separation-individuation phase
D - Psychic representations of external entities
The primary MOA of action of benzodiazepines at GABA-A receptors is to increase which of the following?
(A) Duration of Cl- channel opening
(B) Affinity of the binding sites for GABA
(C) Response of the tonic GABA-activated currents
(D) Long open state, and reduces the short open state
(E) Frequency of channel opening in response to GABA
E - Frequency of channel opening in response to GABA