Absorption of drugs
In cell membrane the hydrocarbon chains for hydrophilic phase and the polar heads form hydrophobic phase.
a.True
b.False
c.May be True or False
False (Why?)
What does the word “open” mean in the one compartment open model?
a.The drug easily enters
b.The drug readily mixes with the blood
c.Unidirectional input and output
d.Easy absorption
Unidirectional input and output
What is a prodrug?
a.An excipient which helps in creating the environment for the drug-dissolving
b.Chemically drug precursor
c.Excipient of drug formulation
d.A drug which is used by professionals
Chemically drug precursor
Proteins interact with which part of the cell membrane?
a.Hydrophobic tail
b.Polar head
c.Non polar head
d.Hydrophilic tail
Polar head
How much time does an intravenously administered drug take to complete a complete circulation?
a.5-8 min
b.7-10 min
c.1-3 min
d.1 min
1-3 min
Which of the following is the correct characteristic of bio precursors/ metabolic precursors?
a.The inert carrier is attached through a chemical bond
b.There is no inert carrier
c.There is a change in pH while the formulation
d.The active drug is converted to its inert form chemically
The active drug is converted to its inert form chemically
Which part of the membrane is responsible for the relative impermeability of polar molecules in and out of the cell?
a.Polar head
b.Hydrophobic head
c.Hydrophobic core
d.Non polar head
Hydrophobic core
What is meant by elimination half-life?
a.Time take for half of the amount of drug to get completely eliminated from only the organs
b.Time take for half of the amount of drug to get completely eliminated from only blood
c.Time take for half of the amount of drug to get completely eliminated from only plasma
d.Time take for half of the amount of drug to get completely eliminated from the body as well as plasma
Time take for half of the amount of drug to get completely eliminated from the body as well as plasma
Prodrugs with two active compounds are known as ___________
a.Mixed type prodrugs
b.Pro-prodrugs
c.Bioprecursors
d.Mutual prodrug
Mutual prodrug
What helps in the passing of inorganic ions?
a.Ion channels
b.Voltage gated channels
c.Aqueous filled pores
d.Diffusion
Aqueous filled pores
What is the equation to find out hepatic clearance?
a.Plasma drug concentration/rate of elimination by the kidney
b.Rate of elimination by kidney/plasma drug concentration
c.1 / rate of elimination by the kidney
d.1 / plasma drug concentration
Rate of elimination by kidney/plasma drug concentration
Which of the following is not a characteristic of ideal prodrug?
a.Should rapidly transform, chemically and enzymatically forming the active product
b.Should have intrinsic pharmacological activity
c.The vapour pressure should be less and evaporate easily
d.Apart from an active product, other metabolic fragments should be nontoxic
The vapour pressure should be less and evaporate easily
The cell membrane is ___________
a.Impermeable
b.Semipermeable
c.Permeable
d.Permeable to only gases
Semipermeable
Which organs comprise the central compartment in a two compartment model?
a.Muscles
b.Skin
c.Adipose
d.Liver
Liver
Which of the following is an example of a mutual prodrug?
a.Prontosil is the prodrug for sulfanamide
b.Aspirin is the prodrug of salicylic acid
c.Benorylate prodrug for NSAIDs and paracetamol
d.Diesters pro-prodrug for pilocarpic acid
Benorylate prodrug for NSAIDs and paracetamol