Dopamine Pathways
Which dopamine pathway regulates movement and coordination?
A. Mesolimbic
B. Mesocortical
C. Nigrostriatal
D. Tuberoinfundibular
C. Nigrostriatal
First-generation antipsychotics block which receptor?
A. 5-HT₂A
B. D₂
C. GABA-A
D. NMDA
B. D₂
A patient becomes restless six days after starting fluoxetine. Likely cause?
A. Bipolar mania
B. Activation syndrome
C. Akathisia D. Panic attack
B. Activation syndrome
Which medication treats EPS?
A. Propranolol
B. Benztropine
C. Buspirone
D. Mirtazapine
B. Benztropine
Which pathway’s underactivity causes negative symptoms?
A. Mesolimbic B. Mesocortical
C. Nigrostriatal D. Limbic
B. Mesocortical
EPS (tremor, rigidity) occurs from dopamine blockade in which pathway?
A. Mesocortical B. Nigrostriatal
C. Mesolimbic D. Tuberoinfundibular
B. Nigrostriatal
Atypical antipsychotics affect both dopamine and which receptor?
A. 5-HT₂A
B. GABA C. Glutamate D. Muscarinic
A. 5-HT₂A
Grandiosity, pressured speech, and risky behavior indicate:
A. MDD B. PTSD C. Bipolar I (mania)
D. OCD
C. Bipolar I (mania)
Which antipsychotic causes the greatest weight gain?
A. Aripiprazole B. Lurasidone
C. Olanzapine D. Ziprasidone
C. Olanzapine
Early agitation after SSRI initiation—management?
A. Stop immediately
B. Lower dose/add benzodiazepine
C. Add antipsychotic D. Increase dose
B. Lower dose/add benzodiazepine
Which pathway mediates reward and addiction?
A. Mesocortical B. Nigrostriatal
C. Mesolimbic D. Hypothalamic
C. Mesolimbic
Clozapine reduces suicide risk in which disorder?
A. PTSD B. Depression C. Schizophrenia D. OCD
C. Schizophrenia
Flashbacks, nightmares, and hypervigilance indicate:
A. Bipolar II B. PTSD C. Panic Disorder
D. GAD
B. PTSD
Which mood stabilizer reduces suicide risk in bipolar disorder?
A. Valproate B. Lamotrigine C. Lithium D. Topiramate
C. Lithium
PTSD + alcohol use disorder—best combination therapy?
A. Naltrexone + SSRI
B. Benzodiazepine + CBT
C. Haloperidol + Disulfiram
D. Lithium + Buspirone
A. Naltrexone + SSRI
Hyperactivity in this pathway leads to hallucinations and delusions:
A. Mesolimbic B. Nigrostriatal
C. Mesocortical D. Tuberoinfundibular
A. Mesolimbic
Dopamine blockade in this pathway increases prolactin:
A. Mesolimbic B. Mesocortical
C. Tuberoinfundibular D. Nigrostriatal
C. Tuberoinfundibular
Hallucinations and delusions result from which pathway’s overactivity?
A. Mesocortical B. Mesolimbic
C. Nigrostriatal D. Hypothalamic
B. Mesolimbic
Alpha-1 blocker used for PTSD nightmares:
A. Prazosin B. Clonidine C. Trazodone D. Buspirone
A. Prazosin
Severe psychosis with suicidality—best medication?
A. Risperidone B. Aripiprazole
C. Clozapine D. Ziprasidone
C. Clozapine
Decreased dopamine activity here causes flat affect and apathy:
A. Nigrostriatal B. Mesocortical
C. Mesolimbic D. Tuberoinfundibular
B. Mesocortical
Which antipsychotic requires CBC monitoring due to agranulocytosis?
A. Risperidone B. Aripiprazole
C. Clozapine D. Olanzapine
C. Clozapine
Haloperidol-induced tremor and rigidity are due to:
A. EPS B. Mania C. Akathisia D. Sedation
A. EPS
Hyperprolactinemia with risperidone results from:
A. Serotonin blockade
B. D₂ blockade in tuberoinfundibular pathway
C. GABA inhibition D. Glutamate excess
B. D₂ blockade in tuberoinfundibular pathway
Fever, rigidity, and confusion after antipsychotic use indicate:
A. Serotonin syndrome B. EPS
C. Neuroleptic Malignant Syndrome
D. Mania
C. Neuroleptic Malignant Syndrome