Classical complement Pathway
Which component initiates the classical pathway in the complement system?
C1q
The C3 convertase of the alternate pathway (C3bBb) is stabilized by which protein?
Properdin (Factor P)
What specific sugar residue on pathogens does MBL primarily recognize?
Mannose
The classical complement pathway is primarily initiated when the C1q subcomponent binds to which of the following
The Fc region of antigen-bound antibody
Which complement factor is cleaved by factor D to form the key C3 convertase (C3bBb) of the alternative pathway?
FactorB
The MBL complex includes associated proteases known by what acronym?
MASPs
What is the molecular composition of the C3 convertase in the classical pathway?
C4b2a
The terminal phase of the pathway results in the formation of what structure that creates a pore in the pathogen membrane, leading to its death?
MAC
The lectin pathway is considered a part of which type of immunity (one word)?
Innate
At which specific complement component do the classical, alternative, and lectin pathways all converge
C3
What specific function does C3b perform by coating the surface of pathogens, making them easier targets for immune cells?
Opsonization
What is the name for the small fragments (C3a, C4a, C5a) that act as inflammatory mediators?
Anaphylatoxins
Which subcomponents of the C1 complex possess enzymatic activity once a conformational change is induced by binding?
C1r and C1s
Does the alternative pathway require antibodies for its initiation?
No
What protein in the lectin pathway binds to pathogen-associated carbohydrate patterns?
MBL