Defintions
What is the order of the cell cycle?
What is:
1) Initiation
2.) Promotion
3.) Transformation / conversion
4.) Progression
Time until cancer worsens progression of stage or metastasis or not responding to therapy
What is progression free survival
BSA formula
C
Cisplatin , Carboplatin = Nephro and Oto
What is the definitive way to know someone has cancer?
What is Biopsy **** BONUS points if you can say what it is also called?
Number of patients alive after five years
this drug does not use BSA
Carboplatin
D
Docorubicin = cardiotoxcoty, Alopecia
After the 1st cycle you've killed 90% of cancer cells in body, after 2nd cycle you've killed 50% of what was left.
What is log kill hypothesis
What is complete response
Carboplatin use
AUC x (Crcl + 25)
F
5FU - Myelosupression, Mucositis, photosensetivity, hand and foot syndrome
Performace status of what number can get chemo therapy?
0,1,2
20-30% of cancer cells left
What is partial response
What is the CrCL rules?
TBW > IBW < 120 use IBW
TBW > IBW > 120 adj
P
cyclophosphomide ; hemorrhagic cystitis
What is disease free
More than 20% increase in cancer cells
What is progressive disease
CRCL
IBW
(TBW - IBW) x 0.4 + IBW
50 M
45.5 W
T/V
Taxane = paclitaxel, docetaxel
V = Vinorelbine
PN