Bugs Pt 1
World Cup
Drugs Pt 1
Arizona
Beta Lactams
100
List 5 antibiotics that have pseudomonal coverage.
-Piperacillin-tazobactam
-Cefepime
-Ceftazidime
-Meropenem
-Cipro/Levaquin
-Tobramycin
-Imipenem-cilastatin
-Doripenem
-Aztreonam
-Ceftolozane-tazobactam
-Ceftazidime-avibactam
-Imipenem-relebactam
-Cefiderocol
100
Which country has won the most FIFA World Cups? And how many?
Brazil has won 5 (!) world cups
100
Aminoglycosides carry significant risk for these two major organ toxicities, one of which can be irreversible.
nephrotoxicity and ototoxicity
100
What county is Phoenix in?
Maricopa
100
What cephalosporin is excreted through the biliary tree?
Ceftriaxone
200
This gram-positive coccus has never developed resistance to penicillin, making penicillin G the drug of choice for infections caused by this organism.
Streptococcus pyogenes (Group A Streptococcus)
200
This nation reached three World Cup Finals but has never lifted the trophy.
Netherlands
200
What antibiotic has the most reliable pseudomonal coverage at MCA (by the antibiogram)?
Cefepime
200
This bird, commonly found nesting in saguaro cacti, is Arizona's state bird.
Cactus Wren
200
This 3rd generation "pseudomonal" cephalosporin is the least active cephalosporin against gram-positive organisms and should NOT be considered adequate coverage for staphylococci or streptococci.
Ceftazidime
300
Stenotrophomonas maltophilia is an [aerobic or anaerobic?], glucose non-fermenting, gram-[positive or negative?] [coccus, bacillus, coccobacillus?] that is ubiquitous in aqueous environments and has emerged as an important multidrug-resistant opportunistic nosocomial pathogen.
Aerobic, gram-negative bacillus
300
How many times has a team won the world cup with a foreign coach?
Zero
300
A 28-year-old woman with uncomplicated cystitis is prescribed nitrofurantoin 100 mg BID for 5 days. Which patient characteristic would be a contraindication?
- A) CrCl 45 mL/min
- B) CrCl 25 mL/min
- C) Age 28 years
- D) Non-pregnant status
- B) CrCl 25 mL/min
300
This Arizona observatory discovered Pluto in 1930.
Lowell Observatory
300
This oral 3rd-generation cephalosporin has only 25% bioavailability and less than 20% urinary excretion, leading to significantly higher treatment failure rates for UTIs compared to cephalexin.
Cefdinir
400
A patient with Enterobacter cloacae bacteremia is started on ceftriaxone. On day 3, repeat cultures remain positive. What is the most likely mechanism of resistance?
AmpC beta-lactamase derepression (inducible AmpC)
400
Extended infusions of beta-lactams optimize efficacy by maximizing this pharmacodynamic parameter, with a goal of greater than 100%.
Time above MIC (T>MIC)
400
This Arizona city has the highest average annual temperature in the state and is known as one of the sunniest places on Earth.
Yuma
400
Name the two preferred beta-lactam options for treating infections caused by AmpC-producing Enterobacterales such as Enterobacter cloacae.
4th generation cephalosporins (cefepime), carbapenems
Novels: Ceftazidime-avibactam, Meropenem-vaborbactam, Imipenem-cilastatin-relebactam,
Cefiderocol
500
Name four organisms or organism groups that carbapenems have NO activity against.
MRSA, Enterococcus faecium, Stenotrophomonas maltophilia, and atypical organisms (Chlamydia/Mycoplasma)
500
Two coaches are tied for the record of most FIFA World Cup victories as head coach, each with 2 World Cups. Name both coaches and the years they won.
(1) Vittorio Pozzo (Italy: 1934, 1938) and (2) Helmut Schön (West Germany: 1954, 1974)
500
This monobactam is stable against metallo-beta-lactamases and is given in combination with avibactam for NDM-producing CRE.
aztreonam
500
The Arizona Cardinals originally played in this Midwestern city before relocating to Arizona.
Chicago
500
Ceftazidime shares a side chain with this monobactam, and the two drugs should be thought of similarly in terms of spectrum.
Aztreonam
