Primary Stroke Prevention
This dietary pattern is recommended by the 2024 AHA guideline to reduce primary stroke risk.
What is the Mediterranean diet?
This thrombolytic is now preferred over alteplase in the 2026 guideline.
What is tenecteplase?
Both CHANCE and POINT evaluated this antiplatelet regimen.
What is clopidogrel plus aspirin (dual antiplatelet therapy)?
Finding this on the initial head CT absolutely contraindicates thrombolytic therapy.
What is intracranial hemorrhage?
A patient presents with a minor ischemic stroke two hours after symptom onset and qualifies for thrombolysis. According to the 2026 guideline, this medication should be administered.
What is tenecteplase?
According to the 2024 guideline, this class of diabetes medications is recommended for patients with diabetes and high cardiovascular risk because it also lowers stroke risk.
What are GLP-1 receptor agonists?
The recommended dose of tenecteplase for acute ischemic stroke is this.
What is 0.25 mg/kg IV bolus (maximum 25 mg)?
Unlike POINT, this trial found no increase in moderate or severe hemorrhage with dual antiplatelet therapy.
What is CHANCE?
This catastrophic vascular emergency is an absolute contraindication to IV thrombolysis because treatment may worsen mortality.
What is aortic dissection?
A patient with minor stroke receives TNK. Aspirin should generally be delayed for this amount of time.
What is 24 hours?
The updated guideline specifically recommends screening patients for this non-medical factor because it influences stroke prevention and access to care.
What are social determinants of health?
Before administering IV thrombolytics, blood pressure should be below this value.
What is 185/110 mmHg?
POINT used this loading dose of clopidogrel.
What is 600 mg?
This active cardiac infection is considered an absolute contraindication because of the high risk of intracranial bleeding from septic emboli.
What is infective endocarditis?
A patient with a minor ischemic stroke is treated with dual antiplatelet therapy. According to CHANCE and POINT, this medication should ultimately be discontinued while aspirin is continued.
What is clopidogrel?
Treatment of this blood pressure threshold during pregnancy and up to six weeks postpartum is recommended to reduce maternal intracerebral hemorrhage.
What is SBP ≥160 mmHg or DBP ≥110 mmHg?
After thrombolytic administration, blood pressure should remain below this threshold.
What is 180/105 mmHg?
CHANCE used this loading dose of clopidogrel.
What is 300 mg?
Rather than using rigid exclusion criteria, the updated TNK recommendations emphasize this approach when evaluating many relative contraindications.
What is an individualized risk-benefit assessment?
A patient presents 18 hours after last known well with a large vessel occlusion and favorable perfusion imaging but cannot undergo thrombectomy. According to the 2026 guideline, this reperfusion strategy may still be considered.
What is IV thrombolysis (tenecteplase)?
The guideline recommends evaluating patients for these three female-specific conditions because they are associated with increased future stroke risk.
What are endometriosis, premature ovarian failure, and early menopause?
According to the 2026 guideline, IV thrombolysis may be considered up to this time in selected patients with favorable perfusion imaging but who are not candidates for thrombectomy.
What is up to 24 hours from last known well?
Current practice recommends approximately this duration of dual antiplatelet therapy after minor ischemic stroke or high-risk TIA because the benefit is greatest early while bleeding risk increases with prolonged therapy.
What is 21 days?
A patient with a recent gastrointestinal bleed, pregnancy, and recent surgery illustrates this category of thrombolytic exclusions.
What are relative contraindications?
A 45-year-old woman with diabetes, obesity, hypertension, and a history of preeclampsia presents for primary prevention counseling. Name three guideline-supported interventions or evaluations that would reduce her future stroke risk.
What are any three of the following?