On Target
Lorlatinib
CROWN (7years)--> PFS 55%, high CNS penetration
What is ALK?
Owing to my adventurous spirit, my sister and I trekked to Africa and summitted Mt. Kiliminjaro in 2024.
Who is Mona?
What is KATHERINE?
Marking a major breakthrough in cancer care, ipilimumab becomes the first immunotherapy approved for the treatment of metastatic melanoma.
What are the 2010's?
Dermatitis, colitis, nephritis
What are immunotherapies?
Durvalumab
11 indications, 7 tumor types, 1st indication metastatic urothelial
What is PDL-1?
I have many hats to go with my many talents: Nurse, Mom, Adminstrator.... and don't forget amateur beekeeper.
Who is Chantiel?
An anatomical variation of blood vessels this can commonly lead to isolated, extensive DVT of the LLE
What is May Thurner Syndrome?
"Modern" cancer chemotherapy begins when Yale University pharmacologists Louis Goodman and Alfred Gilman administer the first IV chemotherapy drug, Nitrogen Mustard, to a patient with advanced lymphoma.
What are the 1940's?
Peripheral neuropathy, kidney damage, hearing loss
What are the platinums?
Lenvatinib (5)
What is multikinase inhibitor (VEGF, FGFR, PDGFR, KIT,RET)?
A lover of animals, my dream is to live on a small farm with fainting goats, chickens and mini donkeys. Perhaps even a Llama. For now, I make due with my cats
Who is Amy?
Causing an isolated, typically quite prolonged PTT, this autosomally recessive inherited disorder causes no signs or symptoms of clinical bleeding.
What is the Hagemann Factor (XII)?
The introduction of trastuzumab (Herceptin) for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer ushers in the era of targeted therapy, in which a drug or other substance is developed to identify and attack specific cancer cells while minimizing damage to healthy cells.
What are the 1990's?
Myelosuppression, mucositis, secondary AML
What are the topoisomerase 2 inhibitors?
Fostamatinib
There is organized, and then there is me. As I never leave anything to chance, my husband affectionately titled me the "Master Planner".
Who is Brittney?
Say it ain't so Trousseau.... having earlier in life described the phenomenon of a migratory superficial thrombophlebitis associated with the presence of an occult visceral malignancy, he later died from this type of cancer
What is gastric cancer?
What are the 1950's?
Bruising, diarrhea, cardiac arrythmias
What are the BTK inhibitors?
Enfortumab-vedotin
What is nectin-4?
An accomplished athlete growing up, I was a member of my high schools State Champion lacrosse team. Oh, and I can still juggle a soccer ball 100 times.
Who is Kathleen?
Malignant lymphocytes can undergo a metabolic shift, preferentially using glycolysis for energy production. This leads to lactic acidosis without accompanied hypoperfusion or hypoxia.
What is the Warburg Effect?
Ancient Greek physician Hippocrates introduced the word karkinos, meaning “crab,” to describe tumors, likely in reference to their appearance as they metastasize.
What is 400 BC?
What are the bispecifics?