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This lymphoma often affects young men, involves spleen, liver, and marrow sinusoids, frequently expresses gamma-delta TCR, and is associated with isochromosome 7q.
What is hepatosplenic T-cell lymphoma?
This leukemic CTCL is defined by erythroderma, generalized lymphadenopathy, clonal blood involvement, and malignant CD4 cells often losing CD7 and CD26.
What is Sezary syndrome?
The findings of an MYD88 L265P mutation and IgM monoclonal protein supports the diagnosis the diagnosis of the condition.
What is Waldenström macroglobulinemia?
In 2026, the FDA approved this regimen for pediatric patients 12 years and older with previously untreated stage III or IV classical Hodgkin lymphoma.
What is nivolumab plus AVD?
When defined appropriately this post-frontline clinical event, not a baseline score, identifies a follicular lymphoma group with strikingly inferior survival after immunochemotherapy.
What is POD24?
This intestinal T-cell lymphoma is linked to celiac disease and classically arises in the jejunum or ileum with ulceration or perforation.
What is enteropathy-associated T-cell lymphoma?
In mycosis fungoides, this adverse histologic event is usually defined by large cells comprising at least 25% of the infiltrate or forming microscopic nodules.
What is large-cell transformation?
A historical but foundational histological classification system for non-Hodgkin lymphomas originating in Germany.
Kiel classification
In 2025, the FDA approved this ADC with lenalidomide and rituximab for relapsed/refractory LBCL after at least two lines in patient's ineligible for autoHCT or CAR T-cell therapy.
What is brentuximab vedotin?
Gain-of-function mutations in this histone methyltransferase create a rational target for tazemetostat in relapsed follicular lymphoma.
What is EZH2?
In ALK-negative anaplastic large cell lymphoma, rearrangement of this locus predicts a more favorable prognosis, while TP63 rearrangement predicts poor outcome.
What is DUSP22?
This CCR4-directed antibody has particular activity in blood-involved CTCL and may complicate subsequent allogeneic transplantation through Treg depletion.
What is mogamulizumab?
Clusters of malignant T-lymphocytes found in the epidermis, a classic histological feature of cutaneous T-cell lymphomas like mycosis fungoides and Sézary syndrome.
Pautrier's microabscesses?
In 2025, the FDA approved this CD19 CAR T-cell product for relapsed/refractory marginal zone lymphoma after at least two prior lines of systemic therapy.
What is lisocabtagene maraleucel?
The inguinal, CD23-positive, BCL2-rearrangement-negative FL variant often harbouring STAT6 and 1p36 (TNFRSF14) lesions is best thought of as this morphologic variant.
What is follicular lymphoma with predominantly diffuse growth pattern?
This panniculitis-like cytotoxic T-cell lymphoma is typically alpha-beta TCR-positive, CD8-positive, and betaF1-positive, and must be separated from gamma-delta T-cell lymphoma.
What is subcutaneous panniculitis-like T-cell lymphoma?
The name of the randomized trial that established brentuximab vedotin superiority over physician's choice of methotrexate or bexarotene in CD30-positive CTCL.
What is ALCANZA?
An older, historical eponym for a subtype of peripheral T-cell lymphoma (lymphoepithelioid lymphoma) named after a German pathologist.
What is Lennert's Lymphoma?
In 2025, the FDA approved this BTK inhibitor with bendamustine and rituximab for previously untreated mantle cell lymphoma.
What is acalabrutinib?
This mostly pediatric/young-adult FL entity can look cytologically high grade but is usually localized, BCL2-rearrangement negative, and clinically indolent.
What is pediatric-type follicular lymphoma?
This intestinal T-cell lymphoma is typically CD8-positive and CD56-positive, monomorphic, epitheliotropic, and not tightly linked to celiac disease.
What is monomorphic epitheliotropic intestinal T-cell lymphoma?
This MF variant often produces alopecia or acneiform lesions, and may be less responsive to superficial skin-directed therapy.
What is folliculotropic mycosis fungoides?
An obsolete synonym for follicular lymphoma, occasionally found in legacy pathology literature.
What is Brill-Symmers disease?
In 2025, the FDA approved this monoclonal antibody with lenalidomide and rituximab for relapsed/refractory follicular lymphoma.
What is tafasitamab?
This acetyltransferase gene is a frequent early FL lesion; its loss perturbs enhancer acetylation, antigen presentation, and immune-synapse biology.
What is CREBBP?