LYMPHOMA LICENSE PLATE
"POLA EH"
This friendly Canadian physician was 1st seen at an ASH Poster session presenting Pola-BR and helped drive this as a rel/ref DLBCL therapy into every tumor board.
Who is Laurie Sehn?
I am the starry-sky sprinter whose MYC engine runs nearly every cell through the cycle; in one continent I chew the jaw, in another I haunt the ileocecal valve.
What is Burkitt lymphoma?
In WHO-HAEM5, the former follicular lymphoma grade 3B is conceptually separated from classic follicular lymphoma and renamed as this large-cell follicular-pattern entity.
What is follicular large B-cell lymphoma?
This genetic cluster of DLBCL is enriched for MYD88 L265P and CD79B mutations, immune-privileged-site biology, and chronic active BCR/NF-kB signaling.
What is MCD?
In the Hans algorithm, a DLBCL that is CD10-negative, BCL6-positive, and MUM1-negative is assigned to this cell-of-origin category.
What is germinal-center B-cell-like / GCB?
"LONCA U"
This witty physician promoted R-ICE in rel/ref LBCL but went South to greener fairways and IITs that make NCCN guidelines
Who is Craig Moskowitz?
I wear a follicular-helper T-cell cloak, mutate RHOA at G17V, borrow TET2 and DNMT3A from clonal hematopoiesis, and decorate my lymph node with arborizing high endothelial venules.
What is nodal T-follicular helper lymphoma, angioimmunoblastic type?
This aggressive B-cell entity resembles Burkitt lymphoma morphologically but lacks MYC rearrangement and instead shows a characteristic 11q gain-loss pattern.
What is high-grade B-cell lymphoma with 11q aberration?
This DLBCL genetic cluster is enriched for EZH2 mutation and BCL2 translocation and largely maps to the GCB cell-of-origin compartment.
What is EZB?
Making sure your diagnosis matches the presentation this transcription factor is the most useful single IHC marker to support mantle cell lymphoma when cyclin D1 is negative or equivocal.
What is SOX11?
"NO TXP"
This straight-shooting German physician used data to conclude not do consolidative transplant in newly diagnosed mantle cell lymphoma
Who is Martin Dreyling?
I rim adipocytes with CD8-positive cytotoxic alpha-beta T cells; if you call me gamma-delta, you have turned an indolent panniculitic puzzle into a more ominous beast.
What is subcutaneous panniculitis-like T-cell lymphoma?
This large B-cell lymphoma presents as lymphoma confined to a chronic effusion without a tumor mass and is typically HHV8-negative, separating it from classic primary effusion lymphoma.
What is fluid overload-associated large B-cell lymphoma?
This DLBCL genetic cluster is dominated by TP53 abnormality and broad aneuploidy rather than a single targetable pathway lesion.
What is A53?
DLBCL with expression of this pan-T-cell-associated antigen has a recognized association with older age, extranodal involvement, and increased CNS relapse risk.
What is CD5?
"MOPP ME"
This NCI physician helped turn advanced Hodgkin lymphoma from fatalism into curability with a four-drug mustard-era cocktail.
Who is Vincent T. DeVita Jr.?
I refuse to make a mass because the bloodstream is my architecture; the malignant B cells are large, CD20-positive, and trapped inside small-vessel lumina.
What is intravascular large B-cell lymphoma?
This LBCL of children and young adults often involves Waldeyer ring or cervical nodes, has a GCB phenotype with IRF4 rearrangement of t(6;14).
What is large B-cell lymphoma with IRF4 rearrangement?
This DLBCL genetic cluster is characterized by BCL6 fusions and NOTCH2 pathway lesions and often overlaps biologically with marginal-zone-like programs.
What is BN2?
This rare large B-cell lymphoma is often CD20-negative, expresses plasma-cell markers, and shows cytoplasmic granular staining for a tyrosine kinase as a result of a t(2;17) rather than t(2;5).
What is ALK-positive large B-cell lymphoma?
"MAVORIC"
This Stanford cutaneous lymphoma expert took CCR4 seriously enough to study mogamulizumab versus vorinostat in CTCL.
Who is Youn H. Kim?
I paint the spleen red rather than white, show villous lymphocytes without classic hairy-cell markers, and ask you not to confuse me with BRAF-mutant hairy cell leukemia.
What is splenic diffuse red pulp small B-cell lymphoma?
This DLBCL subtype has scattered large neoplastic B cells in a background rich in reactive T cells and histiocytes, often producing diagnostic confusion with nodular lymphocyte-predominant Hodgkin lymphoma.
What is T-cell/histiocyte-rich large B-cell lymphoma?
This favorable-risk GCB-enriched DLBCL genetic cluster is associated with SGK1 and TET2 lesions rather than BCL2 translocation-dominant biology.
What is ST2?
A mature yet fragile lymphoma that is CD5-positive, CD23-positive, LEF1-positive, and usually cyclin D1-negative most strongly supports this diagnosis rather than mantle cell lymphoma.
What is CLL/SLL?