Gain of Function
This lymphoma is HHV8-driven, usually arises as an effusion without a mass, often co-harbors EBV, and typically lacks CD20 despite B-cell lineage.
What is primary effusion lymphoma?
This lymphoma has frequent 9p24.1 alterations involving PD-L1/PD-L2 and JAK2 and often presents as a bulky anterior mediastinal mass in young women.
What is primary mediastinal large B-cell lymphoma?
Don't bumble around if you see TP53 disruption, CDKN2A/B loss, or MYC activation in a BCL2-rearranged indolent lymphoma as this most often signals transformation to this clinicopathologic category.
What is transformed follicular lymphoma to DLBCL/HGBL?
The POLARIX regimen kept rituximab, cyclophosphamide, doxorubicin, and prednisone, removed vincristine, and added this dose of an antibody-drug conjugate.
What is 1.8 mg/kg?
This CD20xCD3 bispecific knight moves up two doses' levels then at D=15 moves right into its full dose given subcutaneously with and is approved in both LBCL and follicular lymphoma settings.
What is epcoritamab?
This localized EBV-positive ulcerative lesion of mucosa, skin, or GI tract often arises with age-related or iatrogenic immunosuppression and may regress with reduction of immunosuppression.
What is EBV-positive mucocutaneous ulcer?
This indolent skin-limited B-cell lymphoma usually lacks strong BCL2 expression and has excellent disease-specific survival despite frequent local relapses.
What is primary cutaneous follicle center lymphoma?
Like Megan Fox's character, a marrow biopsy shows low-grade follicular lymphoma while a nodal biopsy shows DLBCL confuses medical monitors when you document this term.
What is a discordant marrow?
In the CNS-IPI for DLBCL, involvement of this paired extranodal organ system was added to the five standard IPI variables.
What are the kidneys or adrenal glands?
Don't get checkmated by this toxicity and is the reason CD20xCD3 agents use step-up dosing, steroid premedication, and early-cycle monitoring.
What is cytokine release syndrome?
This aggressive lymphoma is usually CD20-negative, CD138/MUM1-positive, frequently EBV-positive, and characteristically has plasmablastic morphology with recurrent MYC involvement.
What is plasmablastic lymphoma?
This immune-privileged-site DLBCL is enriched for MYD88 and CD79B lesions and requires attention to ocular staging and methotrexate-based therapy.
What is primary CNS lymphoma?
You may need different sized therapeutic rachets when you see two morphologically and immunophenotypically distinct lymphomas occurring in the same anatomic site, such as classical Hodgkin lymphoma and follicular lymphoma in one node.
What is composite lymphoma?
A large B-cell lymphoma with rearrangements of MYC and BCL2 is categorized in this high-grade molecular group and usually drives discussion beyond unmodified R-CHOP.
What is DLBCL/HGBL with MYC and BCL2 rearrangements?
This CD20xCD3 bispecific rook is notable for fixed-duration outpatient-oriented treatment in relapsed follicular lymphoma and after at least two prior therapies.
What is mosunetuzumab?
This mature T-cell leukemia/lymphoma is caused by HTLV-1, often expresses CD25 and CCR4, and may present with hypercalcemia and skin disease.
What is adult T-cell leukemia/lymphoma?
This site-specific DLBCL has a high risk of contralateral organ and CNS relapses, prompting local radiation and CNS-directed prophylaxis considerations.
What is primary testicular DLBCL?
Grimlock would be proud of the diagnostic confusion that nodular lymphocyte-predominant Hodgkin lymphoma causes when transforming to this large B-cell lymphoma pattern rather than classical Hodgkin lymphoma.
What is T-cell/histiocyte-rich large B-cell lymphoma-like transformation?
When intending to do this regimen correctly you should considering doing twice weekly labs in patients with mediastinal large B-cell lymphoma in order to adjust the doses and maximize cure while avoiding mediastinal radiation in many patients.
What is dose-adjusted EPOCH-R?
Don't move sideways when you realize this CD20xCD3 bispecific bishop has a 2:1 CD20:CD3 configuration.
What is glofitamab?
This cytotoxic lymphoma is almost always EBV-positive and is defined by angioinvasion, necrosis, and destructive disease of the nasal cavity or other extranodal sites.
What is extranodal NK/T-cell lymphoma, nasal type?
Often you get a call from the OR for this T-cell lymphoma that is uniformly CD30-positive, ALK-negative, and typically arises around a textured implant.
What is breast implant-associated anaplastic large cell lymphoma?
This molecularly defined aggressive B-cell lymphoma has MYC rearrangement plus BCL2 rearrangement, while MYC/BCL6-only cases no longer carry the same defining label in WHO-HAEM5.
What is HGBL/DLBCL with MYC and BCL2 rearrangements?
Don't get windmilled by repeated CD20-directed therapy, as this tumor-intrinsic mechanism can mediate resistance to both rituximab-based therapy and CD20xCD3 bispecifics.
What is loss or downregulation of CD20?