Can I Add That On
Adult T-cell leukemia/lymphoma is etiologically linked to this retrovirus, making geographic origin and breastfeeding history unexpectedly relevant lymphoma clues.
What is HTLV-1?
The canonical AITL genetic equation adds RHOA G17V to a pre-existing clonal hematopoiesis-like scaffold dominated by these two epigenetic modifiers.
What is TET2 and DNMT3A?
The classic covalent BTK inhibitor escape mutation changes this binding-site cysteine, explaining why a non-covalent inhibitor may retain activity.
What is C481?
This CD20 radioimmunoconjugate paired this CD20 monoclonal antibody to Yttrium-90 and once represented the most elegant, underused lymphoma therapy in the room.
What is ibritumomab tiuxetan?
The S1826-based regimen that displaced BV-AVD for many stage III/IV classical Hodgkin lymphoma patients combines AVD with this PD-1 inhibitor.
What is nivolumab?
The curable infectious driver of many gastric MALT lymphomas is this spiral bacterium, unless translocations such as BIRC3-MALT1 render the lymphoma autonomous.
What is Helicobacter pylori?
IDH2 R172 mutation in AITL creates this competitive oncometabolite, thereby perturbing alpha-ketoglutarate-dependent dioxygenases and the TFH epigenetic state.
What is 2-hydroxyglutarate?
The other 20%, seen in "mutated" follicular lymphoma is mechanistically linked to gain-of-function mutation of this histone methyltransferase.
What is EZH2?
Modern lymphoma radiotherapy generally moved from involved-field volumes toward this smaller, image-guided concept that incorporates pre-chemotherapy disease extent.
What is involved-site radiation therapy?
Large 'popcorn' LP cells that are CD20+, BCL6+, OCT2/BOB1+, and usually CD15-/CD30- point to this Hodgkin-adjacent B-cell lymphoma entity.
What is nodular lymphocyte-predominant B-cell lymphoma?
Immunoproliferative small intestinal disease, a Mediterranean alpha-heavy-chain disease variant of MALT lymphoma, is linked to this organism.
What is Campylobacter jejuni?
Loss-of-function of this histone acetyltransferase family member in follicular lymphoma can reduce antigen presentation and immune visibility, one reason epigenetics and immune escape are not separable phenomena.
What is CREBBP?
Polatuzumab vedotin resistance can be conceptualized around diminished expression or altered internalization of this B-cell receptor component.
What is CD79b?
This iodine-131-labeled anti-CD20 antibody was commercially available then withdrawn despite real lymphoma activity.
What is tositumomab?
In EBV-positive classical Hodgkin lymphoma, this latent viral membrane protein mimics CD40 signaling and converges on NF-kB activation.
What is LMP1?
Some cutaneous marginal zone lymphomas in Europe have been associated with this spirochete, although the strength of the link is geographically variable.
What is Borrelia burgdorferi?
This hidden lesion location in classical Hodgkin lymphoma is clinically potent because it co-amplifies PD-L1/PD-L2.
What is 9p24.1?
A point mutation at this residue is the canonical BCL2 mutation described in venetoclax resistance, although MCL1, BCL-XL, and BAX biology can also dominate.
What is G101V?
For erythrodermic or widespread patch/plaque CTCL, this radiation modality treats the skin envelope rather than a nodal field.
What is total skin electron beam therapy?
The canonical Hodgkin immune-evasion amplicon at 9p24.1 simultaneously increases PD-L1/PD-L2 copy number and dosage of this kinase.
What is JAK2?
Primary effusion lymphoma, multicentric Castleman disease, and KSHV inflammatory cytokine syndrome sit in the biologic orbit of this oncogenic virus.
What is human herpesvirus 8?
This SET1/COMPASS-family methyltransferase is among the most recurrently altered tumor suppressors in follicular lymphoma and DLBCL, making it a quiet but frequent architect of germinal-center lymphomagenesis.
What is KMT2D?
Loss of this adhesion/costimulatory molecule can impair T-cell immune synapse formation and is a plausible resistance axis for T-cell-engaging therapies.
What is CD58 (LFA-3)?
The CD37-directed radioimmunotherapy construct formerly known as Betalutin couples lilotomab with this beta-emitting isotope.
What is Lutetium-177?
The malignant Hodgkin/Reed-Sternberg cell preserves a crippled B-cell transcriptional signature by showing this transcription factor only weakly, not strongly as in most mature B-cell lymphomas.
What is PAX5?