Notable Toxicities
Rhabdomyolysis / Muscle toxicity (1)
Daptomycin
Rare: FQs, macrolides, SMX-TMP
Acute otitis media (drug + dose required!) (1)
Amox or amox/clav; 90 mg/kg/day PO divided q12h
#1 cause of bacterial pharyngitis (1)
GAS (aka Streptococcus pyogenes)
Ertapenem (1)
Acinetobacter
Pseudomonas aeruginosa
Enterococcus
Chelating antimicrobials (2)
~separate from cations~
Fluoroquinolones
Tetracyclines
INSTIs
QT prolongation (2)
Fluoroquinolones
Macrolides
Lefamulin
Azoles
Infections caused by Treponema pallidum (Syphilis) (1)
Penicillin
Acute otitis media (3)
S. pneumoniae, H. influenzae, M. catarrhalis
Cephalosporins (class-wide coverage gap) (1)
Antibiotic classes with significant post-antibiotic effect (2)
Fluoroquinolones
Aminoglycosides
Ototoxicity / Hearing disturbance (2)
Aminoglycosides
Vancomycin
Macrolides (less common)
Candidemia (Candida bloodstream infection) (1)
Echinocandins
*mortality benefit vs. other antifungals!*
Empiric coverage against this bug is ALWAYS required for febrile neutropenia (1)
Pseudomonas aeruginosa
Fluconazole (1)
Molds
Candida krusei
Pharmacodynamic parameter describing beta-lactam bacterial killing
Time > MIC
Voriconazole
Linezolid
Ethambutol
Less common: FQs, tetracyclines, amphotericin B
Complicated UTI / Pyelonephritis (ORALS only!) (2)
Ciprofloxacin or levofloxacin
TMP-SMX
NOT: nitrofurantoin, oral fosfomycin
Infective endocarditis (3)
Staphylococcus, Streptococcus, Enterococcus
Aztreonam (1)
Gram-positive bacteria
Anaerobes
Oral MRSA coverage (3)
SMX-TMP
Clindamycin
Doxy/mino/omadacycline
Linezolid/tedizolid
Delafloxacin
Rifampin (synergy)
Peripheral neuropathy (2)
Linezolid/tedizolid
Metronidazole
Fluoroquinolones
Isoniazid
Ethambutol
NRTIs
Nitrofurantoin
HIV - initial regimen (1)
*Describe a typical first-line regimen using ART drug classes OR specific agent(s)*
Biktarvy (BIC/FTC/TAF)
Dovato (DTG/3TC)
DTG + (TAF or TDF) + (3TC or FTC)
1 INSTI + 2 NRTIs
Neonatal meningitis (4)
GBS (AKA S. agalactiae), L. monocytogenes, GN rods (E. coli, K. pneumoniae)
Tigecycline (1)
Pseudomonas, Proteus, Providencia (Morganella)
Tiger don't Prr
Anti-Pseudomonas agents (5)
Pip/tazo, ceftaz, ceftaz/avi, cefepime, ceftol/tazo, cefiderocol, aztreonam
Mero/imipenem
Cipro/levo/delafloxacin
Tobramycin, amikacin
Colistin, polymyxin B