psoriasis drugs (not biologics)
What topical is 1st line for mild to moderate plaque psoriasis?
Calcipotriene
Name 3 TNF inhibitors
etanercept, infliximab, adalimumab, certolizumab pegol
Name a low potency corticosteroid
(class VI-VII)
hydrocortisone
What OTC agent is available for acne, psoriasis, and general hyperkeratosis?
Salicyclic acid
Name 2 1st generation and 2 2nd generation antihistamines
1st gen: diphenhydramine, hydroxyzine
2nd gen: loratadine, cetirizine
What's the MOA of calcipotriene?
vit D analog binds to receptor inhibiting keratinocyte proliferation and promoting differentiation; reduces IL-17 and Th1 mediated inflammation
Walk me through the specific for how TNF inhibitors work
For extra 100 pts: name 3 ADRs
ADRs:
Name 2 medium potency corticosteroids.
for extra 50 pts: name 3 indications
Indications: Mild to moderate eczema, seborrheic dermatitis, lichen sclerosis, intertriginous psoriasis (short-term)
What's the MOA of podophyllum resin and podofilox? What are they used for? Which is CI in pregnancy?
- bind to microtubules, inhibiting mitosis and causing tissue necrosis
- primarily for genital warts
- podophyllum resin more toxic and CI
This agent is a TCA with H1 and H2 receptor antagonism, plus....anticholinergic and sedative properties
for extra 50 pts: name a fun ADR
Doxepin
QT prolongation
What topical plaque psoriasis drug, also used for folliculitis, activates the aryl hydrocarbon receptor?
Tapinarof
What agent targets the p40 subunit shared by IL-12 and IL-23 which inhibits both Th1 and Th17 pathways?
Ustekinumab
Name a class II drug and a couple indications
- moderate to severe eczema, atopic dermatitis, psoriasis, lichen simplex chronicus
Name the agent that's a pyrimidine analog. What are 2 indications?
Fluorouracil
used for actinic keratosis and superficial basal cell carcinoma
What vasodilator is used to increase hair growth?
Minoxidil
What's the MOA of methotrexate and name 5 ADRs
MOA: Inhibits dihydrofolate reductase, reducing DNA synthesis and suppressing T-cell and cytokine activity
ADRs: common: hepatotoxicity, myelosuppression, mucositis, nausea, fatigue, and pulmonary fibrosis; teratogenic
Name an IL-17 inhibitor. Its highly effective and rapid-acting compared to other bios
For extra 50 pts: name a contraindication
For extra 50 pts: name another serious ADR
Secukinumab
CI in Crohn's and UC
Black box warning for suicidal ideation
Name a class I corticosteroid. where can you apply this?
What agent activates nuclear retinoid X receptors leading to altered gene expression that inhibits tumor growth?
plus 100 pts if you name 3 ADRs
bexarotene
ADRs:
What's the MOA of finasteride?
For extra 50 pts: what's its CI?
oral 5-alpha reductase inhibitor, reduces dihydrotestosterone levels
CI: women use
What are the drug classes for Tofacitinib and Apremilast?
JAK inhibitor
PDE-4 inhibitor
Name a IL-23 inhibitor. what's an advantage of these?
Guselkumab, Risankizumab, tildrakizumab
what other topical anti-inflammatory (NOT steroid) is used for psoriasis, seborrheic dermatitis?
For extra 50 pts: what topical anti-inflammatory is a PDE-4 inhibitor?
- Tar compounds
- Crisaborole
What's the MOA of vismodegib and sonidegib?
oral hedgehog pathway inhibitors
used for adv basal cell carcinoma
What agent is used for female pattern hair loss?
For extra 100 pts: what agent reduces hair growth in hirsutism?
Spironolactone
Eflornithine (ornithine decarboxylase inhibitor)