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100

What blood type is known as the universal donor?

O-negative

100

What was the name of the trade route that connected China to the Mediterranean?

Silk Road

100

Who invented the first successful vaccine, and for what disease?

Edward Jenner, smallpox

100

What is the highest-grossing movie of all time (not adjusted for inflation)?

Avatar

100

What is the only planet in the solar system that rotates on its side?

Uranus

200

How often can a person donate whole blood?

Every 56 days or 8 weeks

200

What three continents were connected by the triangular trade?

Europe, Africa, and the Americas

200

What discovery by Alexander Fleming revolutionized the treatment of bacterial infections?

Penicillin

200

What movie series features a ring that must be destroyed in Mount Doom?

The Lord of the Rings

200

What is the only fruit that has its seeds on the outside?

Strawberry

300

Which organization is the largest blood supplier in the U.S.?

The American Red Cross

300

What precious metal was a major factor in the Spanish colonization of the Americas?

Silver

300

In what decade did the first successful organ transplant take place?

1950s

300

In which movie does the phrase “May the Force be with you” originate?

Star Wars: A New Hope

300

What country consumes the most chocolate per person?

Switzerland

400

What is the rarest blood type in the world?

AB-negative

400

What 18th-century economic system encouraged European nations to hoard gold and establish colonies for trade benefits?

Mercantilism

400

What 19th-century nurse is credited with professionalizing modern nursing?

Florence Nightingale

400

What famous horror film features a masked villain named Michael Myers?

Halloween

400

What was the original name of Mickey Mouse?

Mortimer Mouse

500

What percentage of the U.S. population is eligible to donate blood, but only a small fraction actually does?

About 38%, but less than 10% donate regularly

500

What major agreement in 1994 reshaped trade between the U.S., Canada, and Mexico?

NAFTA – North American Free Trade Agreement, now replaced by USMCA.

500

What breakthrough medical imaging technique, developed in the 1970s, allows doctors to see inside the body without surgery?

MRI – Magnetic Resonance Imaging

500

What was the first animated movie to win an Academy Award for Best Picture nomination?

Beauty and the Beast

500

What is the only letter that does not appear in any U.S. state name?

Q

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