MOA Marvels
Sotyktu binds to and inhibits this kinase, preventing activation of the IL-23 pathway.
Sotyktu is indicated for adults with this type and severity of psoriasis.
What is moderate-to-severe plaque psoriasis?
PASI stands for this measure of skin clearance.
What is Psoriasis Area and Severity Index?
The most common type of infection seen in Sotyktu-treated patients.
What are upper respiratory infections?
This oral competitor is often positioned before injectables in psoriasis treatment.
What is Otezla (apremilast)?
TYK2 inhibition impacts this immune signaling pathway, reducing psoriatic inflammation.
What is the IL-23 pathway
The two pivotal phase 3 trials that supported Sotyktu’s approval.
What are POETYK PSO-1 and POETYK PSO-2?
PASI 75 represents this percentage of improvement in psoriasis symptoms.
What is 75% improvement?
This viral infection, commonly known as cold sores, was reported in trials.
What is herpes simplex (cold sores)?
These two of many IL-23 biologics are competitors to Sotyktu in the psoriasis market.
What are Skyrizi, Ilumya and Tremfya?
Unlike broad JAK inhibitors, Sotyktu’s selectivity for TYK2 provides this type of advantage.
What is a more favorable safety profile?
In POETYK trials, Sotyktu demonstrated superiority over this oral competitor at Week 16.
What is apremilast (Otezla)?
sPGA stands for this physician-assessed score of psoriasis severity.
What is static Physician’s Global Assessment?
Along with acne, this oral condition was a reported side effect.
What are mouth ulcers?
These 2 of many IL-17 inhibitors compete with Sotyktu as an injectable option.
What is Taltz, Cosentyx, Bimzelx, Siliq?
By blocking IL-23, TYK2 inhibition decreases the activity of these immune cells linked to psoriasis.
The primary efficacy endpoints measured in the POETYK trials were these two skin clearance scores.
What are PASI 75 and sPGA 0/1?
Compared to placebo and Otezla, Sotyktu achieved higher rates of this stringent endpoint, representing complete clearance.
What is PASI 100?
Unlike some JAK inhibitors, Sotyktu has not been associated with increased risk of these two major safety concerns.
What are major cardiovascular events and malignancies?
Unlike biologics, Sotyktu offers this advantage for patient preference
What is oral once-daily dosing (QD)?
TYK2 is part of the JAK family. Name two other kinases in the JAK family that Sotyktu does not inhibit.
What are JAK1, JAK2, or JAK3?
Long-term trial data showed Sotyktu maintained durable responses for this many years.
What is 5 years.
Name one key advantage of Sotyktu’s trial results versus biologics in terms of administration.
What is oral administration (no injections required)?
Name two additional side effects beyond infections and acne reported with Sotyktu.
What are inflamed hair follicles (folliculitis) and increase CPKs?
One major differentiator of Sotyktu versus Otezla is its superior rates of these clinical endpoints.
What are PASI 75 and sPGA 0/1 responses (Or PASI 90 and 100)?