B
A condition resulting from the passage of bilirubin into the brain and spinal cord is:
Kernicterus
What is the smallest class of immunoglobulin?
IgG
Another name for Fetal Maternal Bleed test
Rosette Test
RHIG (Rhogam) is indicated for:
Mothers who are Rh negative
What does a Type and Screen consist of?
Forward, reverse, IAT
Maternal antibodies crossing the placenta and hemolyzing fetal RBCs is known as what?
Hemolytic Disease of the fetus and newborn
Historically, what antibody has caused the most cases of HDFN?
Anti-D
What is the largest immunoglobulin?
IgM
Which ABO blood group causes the most cases of ABO-HDFN
O
What do you do after a positive ABSC?
Antibody Panel
Jaundice of the newborn resulting from accelerated red cell destruction
Icterus gravis neonatorum
Initial prenatal testing includes which group of tests?
ABO grouping, Rh typing including weak D (Du), and antibody screening
What disease that cause thrombocytopenia in a fetus has the same mechanism as HDFN only it affects platelets not RBCs?
Fetal & Neonatal Alloimmune Thrombocytopenia (FNAIT)
Which of the following tests serve as a qualitative indicator of a fetal-maternal hemorrhage?
Rosette test
Antigen typing patient and RBCs the patient will be receiving.
Which class of immunoglobulin is able to cross the placenta and enter fetal circulation?
IgG
Define critical titer
That titer at or below which no severely affected infants or stillbirths have been reported
Which of the following tests serve as a quantitative indicator of a fetal-maternal hemorrhage?
KHB
RHIG is indicated for what postpartum circumstance?
Rh neg mom, Rh pos baby
What is antigen typing test for? What should the results be for someone who has an antibody to receive that unit?
Testing reagent antisera against rbcs. Looking for antigen on rbcs. Should be negative on patient to prove that they can make that antibody. Should also be negative for the rbcs that they are receiving because you don't want agglutination to happen.
Which of the following best describes the purpose of performing titers of maternal antibodies?
Used as an indicator of the course and severity of HDFN
What is the objective of an intrauterine transfusion?
Treat fetal anemia
Requirements of blood for intrauterine transfusions?
CMV negative, irradiated, <7days old, hemoglobin S negative
Difference in indirect agglutination and direct
Direct - Doesn't need AHG (IgM is large enough to directly agglutinate rbcs)
Indirect - Needs AHG as a 'bridge' (IgG)
What kind of crossmatch does someone with an antibody need?
IS and AHG