Glowing with Radiation
The effect of radiation exposure prior to 2 weeks of gestation
What is all or nothing?
NSAIDs use during the third trimester is associated with
What is construction of the fetal ductus arteriosus?
Thalidomide use during pregnancy was associated with
What is focomelia?
— percent of newborns have a major congenital malformation at birth
What is 2-3 %?
FDA category label for ondansetron
What is B?
The radiation threshold dose for congenital abnormalities during organogenesis (mGy)
What is 200 mGy?
The following fetal anomaly has been associated to lithium use during pregnancy
What is Ebstein anomaly?
The following malformation have been described with the use of low dose fluconazole
Cardiac malformations
According to the FDA — percent of all birth defects are caused by medications
What is less than 1%?
The following antipsychotic medication is considered teratogenic
What is none?
The amount of radiation in a CT pelvis (mGy)
What is 10-50 mGy?
The following SNRI has been associated with higher risk of cardiac anomalies
What is Paroxetine?
The following 2 malformations have been associated with the use of Nitrofurantoin
What are cleft lip and hypoplastic left heart?
Exposure to a potential teratogenic medication at 9 weeks will cause
What is functional defects and minor malformations?
Potential congenital malformation from misoprostol exposure during the first trimester
What are limb defects?
The minimum amount of radiation exposure to cause severe mental disability between 8-15 weeks gestation (mGy)
What is 60 mGy
The following 2 anticonvulsants have the lowest teratogenic risk
What are levetiracetam and lamotrigine?
When exposed to isotretinoin during the 1st trimester - percent of fetuses will have malformations
What is 30%?
The following is true regarding medications labeled as category C
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-
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-What are teratogenic effects on animal studies?
-What is no animal studies are available?
-What is no adequate studies on pregnant women are available?
The primary concern about the use of ondansetron in the first trimester
What are cardiac septal defects?
Mammogram is classified as a ——— dose examination, with a fetal radiation dose of —— (mGy)
What is very low dose with 0.001 to 0.01 mGy?
Warfarin use use during pregnancy has been associated the 5 following anomalies
What are:
-Nasal hypoplasia with depressed nasal bridge
-Choanal atresia
-Stippled long bone epiphyses
-CNS anomalies
-Microophalmia
Retinoic acid embryopathy can involve the following organs/ systems
What are:
-Face
-Heart
-Thymus
-CNS
Five tenets to determine teratogenicity
What is:
-The defect is completely characterized
-Agent must cross the placenta
-Exposure during a critical developmental period
-Biologically plausible
-Consistent epidemiological findings (2 or more studies)
The following medication has been associated with birth defects more than 2 years after discontinuation
What is acitretin?