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A WBC count is done on an automated impedence cell counter from a patient with the blood picture seen in #1 (nRBC) The WBC count is most likely
Falsely increased due to nRBCs
The familial disorder featuring pseudo-dohle bodies, thrombocytopenia, and large plts is called
May-Hegglin anomaly
In children the most important effect of lead poisoning is on the?
neurologic system
What is the principle of automated impedance cell counters?
Interruption of an electric current by cells
The majority of iron in an adult is a constituent of
hemoglobin
Which of the following does not characterize beta-thalassemia major?
decreased alpha chains result in excess beta chains
What combo of reagents is used to measure hemoglobin
Potassium ferricyanide and potassium cyanide
What is needed for fibrinolysis to occur at a physiologically significant rate?
tPA must bind to fibrin
The following numbers were obtained in evaluation of LAP activity in neutrophils. What is the score?
200 (0+20+60+60+60)
The expected screening test results for a patient with a fibrin stabilizing factor deficiency are
normal prothrombin time and aPTT
A prolonged aPTT result is obtained on a patient diagnosed with DIC. The patient has not yet been treated for this disorder. The most liekly cause of the prolonged aPTT is:
system activation of the coag system depletes some factors more rapidly than the liver can synthesize them
When spherocytes are reported, what is observed on the peripheral blood smear
red cells without a central pallor
A senescent red cell is one that has
lived its lifespan
Which type of leukemia is associated with the best prognosis for a cure?
ALL in children
Which of the following is not a characteristic of aplastic anemia
extramedullary hematopoiesis
Which of the following statements about sickle cell syndromes is false
Hemoglobin S is more soluble in dithionite than normal hemoglobin
Which of the following conditions is not usually associated with marked reticulocytosis
pernicious anemia
A fibrinogen assay is performed on a fibrometer using the standard 1:10 dilution with Owren's buffer. The seconds obtained do not read on the standard curve. An alternate 1:20 dilution is performed and is 400 mg/dL when read off the curve. The conc that should be reported is
800 mg/dL
A specimen is received for a PT and aPTT. A 5mL tube has 2.5mL of blood in it. Expected test results are
PT and aPTT both falsely long
The major storage form of iron is
ferritin
What causes the hemolytic process in G6PD deficiency following oxidant exposure
precipitation of denatured hemoglobin
Thrombocytosis is characteristic of
DIC
The red cells found in lead poisoning characteristically exhibit coarse granules composed of ________that are reported as _______
aggregated ribosomes; basophilic stippling
Which of the following is most frequently associated with the inclusion bodies seen in color plate 8( Howell-Jolly bodies)
post splenectomy
Which of the following is the most useful in the classification of sickle cell trait vs sickle cell disease
percentage of hemoglobin S on electrophoresis