Populations
Patients from which clinical trial were included in this study?
ARCTIC Trial
Complete case analysis
What proportion of real-world (i.e., non-trial) patients did not have complete follow-up data for the main outcome?
61.0%
Trial and real-world patients in this study came from which country?
Norway
How was "time-zero" defined for this study?
Time of initiating anti-rheumatic drug therapy
At which follow-up visit (i.e., month) did the authors observe the highest drop-out rate in the observational study?
Month 24
What was the follow-up period in the ARCTIC trial?
2010-2013
Name 1 of the 5 missing data methods that used censoring (set as drop-out) to account for intermittent missing visits.
(1) String censoring + IPCW
(2) MI + censoring + IPCW
Which of the 5 missing data approaches yielded the highest odds of achieving disease remission at month 6 and 12 of the follow-up period?
Complete case analysis (CC)
What type of study design was used to create the real-world patient cohort (i.e., non-trial patients)? Be specific!
Prospective observational study
In the strict censoring + IPCW approach, the IPCW methods assigns weights to individuals with complete follow-up data corresponding to the inverse of what?
Inverse of their estimated probability of having complete data.
Which of the 5 missing data methods gave the most conservative estimate for achievement of remission at 6, 12, and 24 months?
MI for all missing data
How many total patients were included between the trial and real-world studies?
230 (trial) + 429 (real-world)=659 patients!
When do intermittent missing visits arise in the data?
When patients do not meet for one or more visits, but reenter the study at a later time point.
Describe the missing data pattern and main reasons for missing data for both the trial and observational study populations.
Obs study: Non-monotone missing data pattern;
cause = intermittent missing visits & missing outcome data
Trial: Monotone missing data pattern;
cause = drop-out