Warnings
& Box Warning
& Box Warning
What major boxed warning does trazodone have
Increased risk of suicidal thinking and behavior
What allergy is a contraindication to trazodone?
Hypersensitivity to trazodone or any ingredient.
What side effect means feeling sleepy or tired?
Sedation/somnolence.
What type of medication is trazodone?
Antidepressant
What neurotransmitter does trazodone inhibit reuptake of?
Serotonin (5-HT)
Which age group has an increased risk of suicidal thoughts and behavior?
Children, adolescents, and young adults ages 18–24
What type of antidepressant should not be taken with trazodone?
MAO inhibitors.
What stomach-related side effects can trazodone cause?
Abdominal pain, nausea, vomiting, or upset stomach
What is the brand name of trazodone listed on the coloring page?
Desyrel
What type of receptors does trazodone block that can cause drowsiness?
Histamine-1 receptors
What should patients be monitored for while taking trazodone?
Changes in mood, behavior, or suicidal thoughts.
How long should generally pass after stopping an MAOI before starting trazodone?
14 days.
What side effect means feeling lightheaded or dizzy?
Lightheadedness/dizziness.
What is the generic name of Desyrel?
Trazodone.
What receptors does trazodone block that can cause orthostasis?
Alpha-1 adrenergic receptors
What activity should patients avoid if trazodone affects their alertness?
Driving or activities requiring mental alertness or coordination.
What should patients do when getting up from sitting or lying down?
Rise slowly
What can happen because of orthostatic hypotension?
A drop in blood pressure when standing
Is insomnia an FDA-approved or off-label use?
Off-label
What is trazodone used to treat?
Major depressive disorder
What can happen when trazodone is taken with alcohol or other CNS depressants?
Increased sedation and drowsiness.
What should patients avoid while taking trazodone?
Alcohol and other CNS depressants.
What rare sexual side effect can trazodone cause?
Priapism
What are the three main actions of trazodone?
Serotonin reuptake inhibition, histamine-1 blockade, and alpha-1 blockade.
What is another common use of trazodone?
Insomnia (off-label).