Neurotransmitters Gone Rogue

Cortical Coordinates
Twelve Angry Nerves
What’s the Diagnosis, Doc?
The Root of it All
100

Epilepsy is primarily associated with excessive activity of this excitatory neurotransmitter.

Glutamate

100

This structure serves as the major sensory relay station to the cortex.

Thalamus

100

This structure contains sensory neuron cell bodies just outside the spinal cord.

Dorsal Root Ganglion

100

Abnormal, excessive, and synchronous excitatory neuronal activity in the brain. 


Seizure

100

From Latin meaning “little brain,” this structure plays a major role in coordination and motor learning.



What is the cerebellum?

200

This neurotransmitter is decreased in major depressive disorder. 


Serotonin or 5-HT

200

This lobe is primarily responsible for executive function and decision-making. 



Frontal lobe

200

Cranial nerve responsible for most parasympathetic output.

Vagus nerve (CN X)

200

Degeneration of dopaminergic neurons in the substantia nigra leads to this disorder.

Parkinson's disease

200

Its name comes from the Greek word for “almond,” and it plays a key role in fear and emotional processing 

Amygdala

300

This neurotransmitter is deficient in Parkinson’s disease and modulates the basal ganglia. 


Dopamine

300

This region contains the substantia nigra. 



Midbrain

300

This cranial nerve controls lateral eye movement. 


Abducens nerve (CN VI)

300

Loss of myelin in the CNS due to autoimmune attack describes this disorder. 


Multiple sclerosis

300

From Greek meaning “horse” and “sea monster,” this structure is essential for forming new declarative memories.

Hippocampus

400

Overactivation of NMDA receptors can lead to this type of neuronal damage.

Excitotoxicity

400

This brain region contains the most nerve tracts entering and leaving the cortex. 



Internal Capsule

400

This cranial nerve carries visual sensory information.  

Optic nerve (CN II)

400

Resting tremor, bradykinesia, and rigidity are hallmark symptoms of this disorder. 



Parkinson's disease

400

From Latin meaning “hard mother,” this is the tough outermost meningeal layer protecting the brain.



Dura mater

500

This neurotransmitter is primarily inhibitory in the CNS.

GABA

500

This structure regulates autonomic and endocrine homeostasis



Hypothalamus

500

This mixed cranial nerve mediates facial sensation and mastication.

Trigeminal nerve (CN V)

500

Degeneration of dopaminergic nuclei in the substantia nigra pars compacta affects this system. 

Basal ganglia circuitry

500

From Greek roots meaning “other,” “speech,” and “no,” this language disorder involves difficulty producing or understanding words.



Aphasia

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