Definitions
Definition of RNA sequencing
RNA sequencing = A technique used by scientists to quantify the amount of RNA in a sample
WHEN (The date of the article being published)
The article was published on November 7th, 2024
What are some other new technologies being created for gene expression and regulation?
PacBio and Oxford Nanopore
What is the basis of Artificial Intelligence
Artificial intelligence (AI) is a branch of computer science and engineering
According to our findings, what has the new approach achieved concerning the identification RNA's
According to our findings, the new approach used for identifing short and long non-coding RNAs (ncRNAs) has demonstrated tremendous success
The definition of CDNA
cDNA = also known as complementary DNA, it is synthetic DNA (mostly composed of mRNA)
Who
Researchers at the University of Manitoba led by Dr. Athan Zovoilis
what are the three types of RNA listed?
mRNA, tRNA, and viral RNA's
What is the basis of genomics
Genomics is the study of genes, including interactions of those genes with each other and with the person's environment
FILL IN THE BLANK: A two-step _____________ method boosted the proportion of short _______ and _______ in sequencing data.
A two-step RNA purification method boosted the proportion of short ncRNAs and mRNAs in sequencing data.
Definition of Bioinformatics
Bioinformatics: The use of computers to analyze and interpret biological data, most commonly DNA.
Where (The place the research is taken place)
CancerCare Manitoba’s Paul Albrechtsen Research Institute
What is the bad part of methods mostly targeting mRNA?
It misses out on many other important RNA types, like tRNAs and viral RNAs.
What were the capabilities of the newly developed genomic method
These capabilities include revealing genetic mechanisms behind human health and disease
FILL IN THE BLANKS: This approach beats prior high-performance ___________________ (The scripts that past AI’ used), especially if enriching for _______ (Small Nucleolar RNA’s.)
This approach beats prior high-performance reverse transcriptases (The scripts that past AI’ used), especially if enriching for snoRNA (Small Nucleolar RNA’s.)
The definition of DNA
DNA = The molecule that conatains genetic data for all living organisims while guiding growth and functions
How - (How does the UM researchers identify important clues)
The UM researchers identify important clues in the non-coding segments of our DNA, once referred to as “junk DNA” by mobilizing precision tools. These segments contain clues about the presence of diseases
What are the benefits of using AI in the subject of cancer research? (Give examples)
AI allows us to improve the speed, accuracy and reliability of many techniques. For example, AI-powered software has already been approved by the FDA to help pathologists identify cancerous areas in prostate biopsies with greater precision.
Which tasks were found to be performable by AI, what additional programming were they given.
AI is an intelligent machine that can perform various tasks, including speech and image recognition, natural language processing, autonomous decision-making, and more. They are programmed to think and act like humans.
What has the new approach approved of the ____________ (A technique used to repair damaged DNA during the replication sequence)
the new approach has enhanced accuracy and addressing difficulties with the GSPSSD2.0 DNA polymerase (A technique used to repair damaged DNA during the replication sequence).
Definition of RNA & MRNA
RNA = nucleic acid carried in various biological roles. mRNA (messenger RNA) = a subtype of RNA that carries genetic information from DNA to ribosomes for protein synthesis.
What & Why (Clue, Revealing genetic mechanisms behind human health and disease) & (The intention of filling in the 97% of our genome)
UM researchers developed a new genomics method with the potential to reveal the genetic mechanisms behind human health and disease. They intend to create the “Epitranscriptome Atlas” to fill in the missing 97 per cent of our genome. This new genomics method offers an innovative way to identify root diseases and cancers while advancing the understanding of non-coding RNAs that can cause cancer.
What is the new method called for addressing the capture of broader range non coding RNAs while still being able to sequence mRNA?
A new method called NERD-seq addresses this by capturing a broader range of non-coding RNAs (ncRNAs) while still being able to sequence mRNA.
Why are UM researchers applying next-generation sequencing and bioinformatics?
To magnify the impact of recent advances in AI algorithms
As a group we think that the new genomics method has a lot of potential. By combining AI and genomics, we will be able to further cancer research, learn more about the root cause of diseases such as dementia, and detect genetic diseases earlier. It has a lot of potential, and with this breakthrough, scientists will now be able to leverage next-generation sequencing in the new field of epitranscriptomics.