Key Terms
An aerosol device that delivers the drug in a powdered form, typically with a breath-actuated dosing system
What is a dry-powder inhaler?
Name three common types of aerosol generators used for inhaled drug delivery
What is a small volume nebulizer (SVN), Pressurized Metered Dose Inhaler (pMDI), and Dry-Powder inhaler (DPI)?
Name two advantages of using a pMDI
What is short treatment time, portable, light, and compact, difficult to contaminate, no drug preparation required, reproducible emitted doses
Name three categories of DPI's
What are single-dose DPI, multiple unit dose DPI, and multiple-dose DPI?
Aerosol generators used at home are frequently contaminated with
What is bacteria?
The proportion of nominal or emitted dosed that is inhaled
What is inhaled dose?
Particle size best for reaching the lung periphery
1-5 um
A propellant-free soft mist inhaler
What is Respimat?
Name two advantages of using DPI's
What is small and portable, built-in dose counter, propellant-free, breath-actuated, short preparation and administration time?
How often should you change your aerosol generator
What is every 24 hours?
An aerosol generator producing aerosol particles from liquid base formulations
What is a nebulizer?
Name the aerosol that consists of a single-particle size, and is rare in nature and medicine
What is a monodisperse?
This component provides visual tracking of the number of doses remaining in the pMDI
What is Dose Counter?
Malfunctioning DPI's causes
What is incorrect DPI assembly, failure to discharge medicine, and empty DPI?
DPI's should not be submerged in
What is water?
Delivery of solid or liquid aerosol particles to the respiratory tract for therapeutic purposes
What is aerosol therapy?
Particle size plays an important role in
What is long deposition, particle velocity, and setting time?
Drug delivery with the pMDI is approximately
What is 10-20% of the nominal dose per actuation?
Name two single-dose DPI's
What is Neoinhaler, and HandiHaler?
The plastic container of pMDI should be cleaned at least
What is once a week?
The amount of medication that remains in the nebulizer at the end of treatment
What is residual volume or dead volume?
Lung deposition is dependent on a variety of factors such as
What is the device, the patient, the drug, and the disease?
Initial and frequent_______ of pMDI is required in order to provide an adequate dose.
What is Priming?
Name six multiple-dose DPI's
What is Flexhaler, Twisthaler, Diskus, RespiClick, Ellipta, and Pressair?
When a spacer is used with a pMDI, it should be cleaned_______
What is before first use and then periodically clean based on the manufacturer suggestions?